Effects of verapamil and procainamide on acute atrial electrical remodeling induced by short-term rapid atrial pacing in humans

The Kaohsiung Journal of Medical Sciences
Chih-Sheng ChuWen-Ter Lai

Abstract

Atrial electrical remodeling (ER) after spontaneous or pacing-induced atrial fibrillation has been previously described in humans. We investigated atrial ER induced by a 5-minute period of rapid atrial pacing and the pharmacologic effects of verapamil and procainamide on this atrial ER phenomenon. The atrial effective refractory periods (ERPs) at drive cycle lengths of 400 (ERP 400 ) and 600 (ERP 600 ) ms, at five representative atrial sites (high right atrium [HRA]; proximal, middle and distal coronary sinus; interatrial septum), were determined in 20 patients at baseline and immediately after cessation of a 5-minute period of rapid pacing from the HRA at a rate of 150 bpm. The degrees of atrial ERP 400 and ERP 600 shortening after pacing were calculated as acute atrial ER. The same protocol was repeated in another 15 patients after intravenous administration of verapamil (0.15 mg/kg) and in another 15 patients after intravenous administration of procainamide (15 mg/kg). The results demonstrated that, in the control state acute atrial ER can be significantly demonstrated at each atrial representative site ( p < 0.001). The mean ERP 400 and ERP 600 shortenings were 9 +/- 4% and 8 +/- 4%, respectively. After procainamide infusio...Continue Reading

References

Sep 1, 1989·Journal of Cardiovascular Pharmacology·C Funck-BrentanoR L Woosley
Dec 5, 1989·The American Journal of Cardiology·P Jaillon, M Drici
Oct 1, 1996·Circulation·E G DaoudF Morady
Dec 31, 1998·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·M A WoodE J Wenger
Jan 1, 2000·Cardiovascular Research·R F BoschV Kühlkamp
Jul 6, 2000·Pacing and Clinical Electrophysiology : PACE·T OsakaI Kodama
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·D R Van Wagoner, J M Nerbonne
Jan 24, 2002·Nature·Stanley Nattel
Mar 20, 2002·Journal of Cardiovascular Electrophysiology·Christian SticherlingFred Morady
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Feb 11, 2003·Journal of the American College of Cardiology·Sohail A HassanFred Morady
Dec 9, 2003·Journal of Electrocardiology·Cong-Xin HuangBo Yang
May 20, 2004·Journal of Cardiovascular Electrophysiology·Merritt H RaittJohn H McAnulty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.