PMID: 3125669Jan 1, 1988

Effects of verapamil and timolol on cellular morphometric changes in cat hearts with regional ischaemia

Virchows Archiv. A, Pathological Anatomy and Histopathology
G GreveL Stangeland

Abstract

In twenty-one anaesthetized open chest cats the left anterior descending coronary artery (LAD) was occluded for three hours. Seven cats were pretreated with a bolus injection of Verapamil, followed by a continuous infusion of Verapamil during the ischaemic period. Seven cats were pretreated with a bolus injection of Timolol to a heart rate reduction of 20 beats/min or more and seven cats were given saline. In the latter two groups the cats received a continuous infusion of saline during the period of coronary occlusion. Biopsies were taken from the mid-myocardium of the normal, border and ischaemic zones, as defined by fluorescein staining, and verified by blood flow measurements with radiolabelled microspheres. Standard point counting techniques were used for calculations of fractional volumes of mitochondria, cytoplasm and myofibrils as well as of mitochondrial surface density and surface to volume ratio. We observed a cytoplasmic oedema in the border and ischaemic zones, that was not altered by medical treatment. In the border zone of the control cats there is greater mitochondrial swelling than in the ischaemic zone. This particular swelling is not seen in the treatment groups. However, in the normal and border zones of the...Continue Reading

Citations

Feb 1, 1976·European Journal of Pharmacology·P MouilléE Gauter
Nov 1, 1976·Progress in Cardiovascular Diseases·M E ConollyC T Dollery
Feb 21, 1977·European Journal of Pharmacology·A M LeferG H Osman
May 1, 1978·The American Journal of Cardiology·R A KlonerP R Maroko
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·G GreveL Stangeland
May 1, 1985·Journal of the American College of Cardiology·R A Slutsky, W W Peck
Oct 1, 1985·Journal of Molecular and Cellular Cardiology·H JodalenJ Lekven
Jul 1, 1969·The Journal of Cell Biology·D W Fawcett, N S McNutt
Aug 27, 1981·The New England Journal of Medicine·J Koch-Weser, W H Frishman
Jul 1, 1983·Japanese Circulation Journal·S SugiyamaT Ozawa
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L W DeBoerE Braunwald
Jul 1, 1980·Cardiovascular Research·R A Kloner, E Braunwald
Apr 2, 1981·The New England Journal of Medicine·Norwegian Multicenter Study Group

Related Concepts

Ischemia
Sarcomeres
Coronary Artery Disease
Fluorescein
Myocardium
Coronary Occlusion
Blood Flow
Anterior Thoracic Region
Mitochondria
Obstruction

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