Effects of verapamil and trandolapril in the treatment of hypertension. Trandolapril Study Group

American Journal of Hypertension
F H MesserliW J Elliott

Abstract

The combination of an angiotensin converting enzyme inhibitor with a calcium antagonist has become a common way of treating patients with essential hypertension who respond insufficiently to monotherapy. This double-blind, randomized, parallel, placebo-controlled, multicenter, outpatient study evaluated the antihypertensive efficacy and safety of a calcium antagonist (verapamil SR) and an angiotensin converting enzyme inhibitor (trandolapril) in patients with mild-to-moderate (stages I and II) essential hypertension. Six hundred thirty-one patients were enrolled in this 10-week study. After a 4-week single-blind placebo phase, patients received one of the following daily dosage regimens in a double-blind fashion for 6 weeks: placebo, 4 mg of trandolapril, 240 mg of verapamil SR, or a combination of 4 mg of trandolapril and 240 mg of verapamil SR. Trough sitting diastolic blood pressure was lowered by 4.5 mm Hg, 4.3 mm Hg, and 8.1 mm Hg more than placebo in the trandolapril, verapamil SR, and combination groups, respectively. In the combination group, sitting diastolic blood pressure was significantly lowered (P < .01) by 3.6 mm Hg more than in the trandolapril group and by 3.8 mm Hg more than in the verapamil SR group. An analy...Continue Reading

Citations

Mar 16, 2001·Expert Opinion on Pharmacotherapy·J Widimský
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Balraj S HeranJames M Wright
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Jenny Mh ChenJames M Wright
Apr 3, 2003·The Journal of Clinical Hypertension·Joel M Neutel, David H G Smith
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Apurv KhannaWilliam B White

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