Effects of verapamil on infarct size following experimental coronary occlusion.

Cardiovascular Research
H J SmithR M Norris

Abstract

Open-chest anaesthetized dogs were given verapamil after left anterior descending artery occlusion, and ST-segment alterations and haemodynamic variables were monitored. Verapamil produced a highly significant reduction in ST-segment elevation in the epicardial electrocardiogram and prevented the haemodynamic deterioration seen in the control animals in which ST-segment elevation persisted. The apparent protective effect of verapamil in myocardial ischaemia is discussed in relation to its ability to inhibit selectively the transmembrane fluxes of calcium ions in excitable tissues.

Citations

Aug 11, 1993·Molecular and Cellular Biochemistry·A BorasoR Ferrari
Feb 1, 1980·The American Journal of Cardiology·P L da LuzL V Décourt
Apr 21, 1977·European Journal of Pharmacology·R P KarlsbergR Roberts
Nov 5, 1981·European Journal of Pharmacology·O Fagbemi, J R Parratt
Mar 1, 1988·Journal of the American College of Cardiology·K Przyklenk, R A Kloner
Jan 1, 1984·Experimental Pathology·K A AlanenT J Nevalainen
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L W DeBoerE Braunwald
Feb 1, 1976·Australian and New Zealand Journal of Medicine·H J SmithE A Harris
Feb 1, 1977·British Journal of Pharmacology·R J Marshall, J R Parratt
Jul 1, 1981·British Heart Journal·H DargieD Krikler
Apr 1, 1976·Journal of Pharmaceutical Sciences·P H Morgan, I W Mathison
Jan 25, 1985·The American Journal of Cardiology·K A Reimer, R B Jennings
Jan 25, 1985·The American Journal of Cardiology·M D WinnifordL D Hillis
Sep 1, 1982·Progress in Cardiovascular Diseases·B N SinghC Y Chew
Jan 1, 1979·The American Journal of Cardiology·L H OpieW F Lubbe
Aug 1, 1987·The Journal of Surgical Research·K OurielG L Hicks
Feb 1, 1980·American Heart Journal·J S GeddesJ F Pantridge
Sep 1, 1980·American Heart Journal·L H Opie
Jan 1, 1985·British Journal of Clinical Pharmacology·B J AlpsA Wilson
Jan 30, 1987·The American Journal of Cardiology·R A Kloner, E Braunwald
Oct 1, 1977·The Annals of Thoracic Surgery·R E ClarkP D Henry
Feb 1, 1979·Circulation·J FerlinzW S Aronow

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