Effects of verapamil SR, trandolapril, and their fixed combination on 24-h blood pressure: the Veratran Study

American Journal of Hypertension
Veratran Study Group

Abstract

The Veratran study investigated the antihypertensive efficacy of verapamil sustained release (SR) (180 mg), trandolapril (1 mg), and their fixed combination during a 24-h period. After a 4-week placebo run-in period, 272 patients (age 49 +/- 9 years, mean +/- SD) with essential hypertension and a clinic diastolic blood pressure > or =100 mm Hg were randomized to verapamil, trandolapril, their fixed combination, or placebo for 8 weeks, according to a multicenter double-blind parallel group study design. Clinic and semiautomatic blood pressure at trough and 24-h ambulatory blood pressure were measured at the end of run-in period and after 8 weeks of treatment. In the 234 patients included in the efficacy analysis, run-in clinic and semiautomatic blood pressures were reduced by verapamil, trandolapril, and combined verapamil and trandolapril significantly more than by placebo. The reductions obtained with the combination were significantly greater than those obtained by verapamil alone. Twenty-four-hour average blood pressures were not modified by placebo and were reduced by 8/6 mm Hg (systolic/diastolic) by verapamil, 11/7 mm Hg by trandolapril, and 14/11 mm Hg by the combination of the two drugs. The differences between the effe...Continue Reading

Citations

Oct 8, 1999·Clinical and Experimental Hypertension : CHE·S MoriyamaT Shibano
May 30, 1998·Journal of Cardiovascular Pharmacology·G ManciaC Giannattasio
Nov 27, 2002·Journal of Cardiovascular Pharmacology·Alfredo Quiñones-GalvanEle Ferrannini
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J Widimský

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