Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria

Toxicon : Official Journal of the International Society on Toxinology
Erika Maria Silva FreitasMaria Alice da Cruz Höfling

Abstract

We have previously shown that veratrine, a mixture of alkaloids known as Veratrum alkaloids, produces skeletal muscle toxicity, and there is evidence that veratrine interferes with the energetics of various systems, including cardiomyocytes and synaptosomes. In this work, we explored the effects of veratrine and veratridine, a component of this mixture, in rat skeletal muscle mitochondria and compared the results with those seen in liver mitochondria. Veratrine and veratridine alkaloids caused a significant concentration-dependent decrease in the rate of state 3 respiration, respiratory control (RCR) and ADP/O ratios in isolated rat skeletal muscle mitochondria (RMM), but not in rat liver mitochondria (RLM) supported by either NADH-linked substrates or succinate. The oxygen consumption experiments showed that RMM were more susceptible to the toxic action of Veratrum alkaloids than RLM. The addition of veratrine (250 microg/ml) to RMM caused dissipation of the mitochondrial electrical membrane potential during succinate oxidation, but this effect was totally reversed by adding ATP. These results indicate that there are chemical- and tissue-specific toxic effects of veratrine and veratridine on mitochondrial respiratory chain com...Continue Reading

References

May 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·R F Keeler
Aug 1, 1990·Teratology·M L OmnellK S Brown
Mar 1, 1990·The Journal of Emergency Medicine·A M JaffeL Courtemanche
Jan 1, 1986·The Journal of General Physiology·J B Sutro
May 1, 1985·Pflügers Archiv : European journal of physiology·O V Brazil, M D Fontana
Jan 1, 1969·Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie·W Ulbricht
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Sep 29, 1995·The Journal of Biological Chemistry·M A SchwallerF Moreau
Feb 1, 1995·Journal of Neurochemistry·I LizasoainS Moncada
Aug 26, 1998·Biochimica Et Biophysica Acta·J C ReedS Matsuyama
Sep 3, 1999·Journal of Ethnopharmacology·H Y TsaiY F Chen
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Aug 6, 2000·British Journal of Pharmacology·J JordánV Ceña
Oct 9, 2002·Toxicon : Official Journal of the International Society on Toxinology·Erika Maria Silva FreitasMaria Alice da Cruz-Höfling
Jan 1, 1961·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·O KRAYER
Feb 4, 2006·Microscopy Research and Technique·Erika Maria Silva FreitasMaria Alice da Cruz-Höfling

❮ Previous
Next ❯

Citations

Feb 23, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Christine Rauber-LüthyAlessandro Ceschi
Dec 22, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Irene Gilotta, Miran Brvar
Dec 23, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xuan YeYue Gao
Dec 31, 2014·Journal of Chromatographic Science·Yue CongZongwei Cai
Mar 27, 2018·Toxicon : Official Journal of the International Society on Toxinology·Daniel Batista da CunhaMaurício Ventura Mazzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Microscopy Research and Technique
Erika Maria Silva FreitasMaria Alice da Cruz-Höfling
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L Crawford, B Myhr
Toxicon : Official Journal of the International Society on Toxinology
William A CatterallTodd Scheuer
© 2022 Meta ULC. All rights reserved