PMID: 974878Aug 1, 1976

Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities

Canadian Journal of Physiology and Pharmacology
W Lippman, T A Pugsley

Abstract

The effects of viloxazine, a clinically effective antidepressant, on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake and various related pharmacological activities were determined and compared to those of the tricyclic antidepressants desimipramine, imipramine, and amitriptyline. Viloxazine inhibitied [3H]NA uptake in the mouse and rat heart, being maximally about one half as potent as imipramine with a similar onset, but shorter duration of action than imipramine. The drug did not inhibit [3H]NA uptake in rat medulla or hypothalamus in contrast to desimipramine and imipramine, but it did alter [3H]NA metabolites in a similar manner. Viloxazine, like desimipramine, was a weak blocker of mouse brain 5-HT uptake, but differed from desimipramine as it poteniated 5-HT-mediated functions in the mouse and rat, as did imipramine and amitriptyline, the latter drugs being relatively potent blockers of 5-HT uptake. Viloxazine potentiated the L-DOPA behavioural syndrome in the mouse, antagonized reserpine-induced ptosis and hypothermia in the mouse, and inhibited gastric acid secretion in the rat, but was less potent than the tricyclic antidepressants. No appreciable in vivo inhibition of monoamine oxidase (EC 1.4.3.4.) activity ...Continue Reading

Citations

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·R D PorsoltJ Lavoisy
Dec 22, 1979·Lancet·T R BarnesD T Greenwood
Mar 1, 1979·British Journal of Pharmacology·R S Jones, M H Roberts
Jan 1, 1980·Progress in Neuro-psychopharmacology·M B WallachL D Waterbury
Mar 1, 1989·Pharmacology & Toxicology·C B Dahl, K G Götestam
Mar 1, 1983·Comprehensive Psychiatry·J Ananth
Mar 1, 1977·British Journal of Pharmacology·K G GreinerJ R Wood
Feb 1, 1979·The Journal of Pharmacy and Pharmacology·R S Jones, M H Roberts
Aug 1, 1980·The Journal of Pharmacy and Pharmacology·S A PleeceP H Redfern

Related Concepts

Amitriptyline Hydrochloride
Apokinon
Biogenic Amines
Brain
ratio-Desipramine
Drug Augmentation
Gastric Juice
Tofranil
Levopa
Morpholines

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