Effects of vincristine on normal and stimulated megakaryocytopoiesis in the rat.

British Journal of Haematology
S EbbeF Stohlman

Abstract

Vincristine was given to rats in which thrombocytopoiesis was either normal or acutely or chronically stimulated by injections of heterologous antiplatelet serum. A single dose of 0.3 mg/kg was given intravenously. The drug produced an early and a delayed megakaryocytopenia suggesting that it was toxic to differentiated megakaryocytes as well as to proliferating stem cells. The results support the hypothesis that vincristine-induced thrombocytosis may be due to homeostatic adjustments which, in turn, are activated as a result of drug-induced cytotoxicity.

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Citations

Nov 1, 1976·The Journal of Clinical Investigation·P A BunnS S Ford
May 30, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Todd M FreebergTerry J Ord
May 1, 1984·British Journal of Haematology·R A Harris, D G Penington
Jul 1, 1978·Journal of Cellular Physiology·S Ebbe, E Phalen
Sep 1, 1977·Scandinavian Journal of Haematology·P KlenerF Kornalík

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