Effects of Viola mandshurica on Atherosclerosis and Hepatic Steatosis in ApoE[Formula: see text] via the AMPK Pathway

The American Journal of Chinese Medicine
Sun Haeng ParkHo Kyoung Kim

Abstract

Atherosclerosis was previously thought to be a disease that primarily involves lipid accumulation in the arterial wall. In this report, we investigated the effect of Viola mandshurica W. Becker (V. mandshurica) water extract on atherosclerosis in apolipoprotein E deficient (ApoE[Formula: see text]) mice. The administration of V. mandshurica to high-fat diet-fed mice reduced body weight, liver weight, and serum levels of lipids (total cholesterol, low-density lipoprotein-cholesterol, triglycerides), glucose, alanine transaminase, and aspartate transaminase. Histopathologic analyses of the aorta and liver revealed that V. mandshurica attenuated atherosclerotic lesions and reduced lipid accumulation, inflammatory responses and fatty acid synthesis. V. mandshurica also increased phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), thereby reducing acetyl-CoA carboxylase (ACC) in liver tissue and inhibiting sterol regulatory element-binding protein 1c (SREBP-1c). V. mandshurica reduced protein expression levels of adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin) as well as ACC, fatty acid synthase, and SREBP-1c. In addition, quantitative analysis of V. m...Continue Reading

References

Mar 20, 2002·Current Molecular Medicine·H S Kruth
Mar 21, 2002·Journal of Agricultural and Food Chemistry·Miao-Jane LeeChau-Jong Wang
Jun 6, 2003·International Journal of Pharmaceutics·D PrabakaranSuresh P Vyas
Nov 5, 2005·Molecular Nutrition & Food Research·Daniel Steinberg
Jan 18, 2006·Cell·Joseph L GoldsteinMichael S Brown
Apr 15, 2006·The Journal of Physiology·Hiroyuki MotoshimaEiichi Araki
Mar 2, 2011·Cell Metabolism·Guido T Bommer, Ormond A MacDougald
May 3, 2012·Annals of the New York Academy of Sciences·Lina Badimon, Gemma Vilahur
Sep 15, 2012·The Journal of Nutritional Biochemistry·Kyeong-Mi ChoiHwan-Soo Yoo
Sep 3, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Hui ChenGuowen Liu
Jun 1, 2014·Environmental Toxicology and Pharmacology·Yoon-Young SungHo Kyoung Kim

❮ Previous
Next ❯

Citations

Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hyeong-Geug KimChang-Gue Son
Jul 22, 2021·Journal of Cellular Physiology·Yu-Sheng QinChao-Ke Tang
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinru HanShuwen Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.