Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial

Nutrients
Estefanía Sánchez-RodriguezMaria D Mesa

Abstract

The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No ef...Continue Reading

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Citations

Aug 28, 2019·Journal of Clinical Medicine·Ángel Fernández-AparicioEmilio González-Jiménez
Sep 11, 2019·Nutrients·Avilene Rodríguez-LaraJesús R Huertas
Aug 10, 2019·Nutrients·Gabriela MarcelinoRita de Cássia Avellaneda Guimarães
Sep 4, 2019·Journal of Food Science and Technology·Damián MaestriJuan de Dios Alché
Sep 27, 2018·International Journal of Molecular Sciences·Ganapathy SivakumarLuigi Gentile
Apr 17, 2020·Nutrition Reviews·João Tomé-CarneiroAlberto Dávalos
Mar 1, 2019·Nutrients·Omorogieva Ojo
Jan 10, 2020·Oxidative Medicine and Cellular Longevity·Giorgio AquilaPaola Rizzo
May 27, 2020·Cardiovascular Therapeutics·Flavia FranconiAnnalisa Romani
Oct 22, 2020·Nutrients·Juan José Hidalgo-MoraAntonio Cano
Nov 3, 2020·Oxidative Medicine and Cellular Longevity·Natalia Di PietroCaterina Pipino

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Methods Mentioned

BETA
PMA
ELISA

Clinical Trials Mentioned

NCT02520739

Software Mentioned

General ASDE
CSG
Statistical Package for the Social Sciences
SPSS
EUROLIVE

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