Effects of Virologic Response to Treatment on Short- and Long-term Outcomes of Patients With Chronic Hepatitis B Virus Infection and Decompensated Cirrhosis

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Jeong Won JangKwang-Hyub Han

Abstract

Little is known about the effects of antiviral therapy on short- and long-term survival of patients with hepatitis B virus (HBV)-related decompensated cirrhosis. We aimed to determine whether a maintained virologic response (MVR, defined as persistent undetectable HBV DNA during therapy) associates with short-term (6 mo) and long-term (6-120 mo) survival of patients with decompensated cirrhosis. We performed a 10-year observation analysis using data from the Epidemiology and Natural History of Liver Cirrhosis study of patients with decompensated liver cirrhosis in Korea. Of the entire cohort (1595 patients enrolled at onset of decompensation since 2005), our analysis comprised 295 patients who immediately began treatment with entecavir (n = 179) or lamivudine (n = 116) after decompensation. We collected laboratory test results, data on hepatocellular carcinoma (HCC) development, and Child-Turcotte-Pugh and model for end-stage liver disease (MELD) scores. The mean follow-up time was 62.3 ± 36.5 months. The primary end point was time of liver transplant-free survival. The median survival time was 7.7 years; 60.1% of patients survived for 5 years and 45.7% survived for 10 years without liver transplantation. An MVR was observed in...Continue Reading

Citations

Jan 11, 2020·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Nov 6, 2018·World Journal of Gastroenterology : WJG·Young-Cheol JuHyun-Woo Oh
Mar 16, 2019·Digestive Diseases and Sciences·Jordan J Feld, Lisette A P Krassenburg
Oct 9, 2020·BioMed Research International·Hong ZhaoWen Xie
Jan 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Zhong-Bin LiDong Ji
Feb 17, 2021·Phytotherapy Research : PTR·Sofi Imtiyaz AliShowkat Ul Nabi
Mar 10, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yameng SunHong You
Apr 10, 2021·The American Journal of Gastroenterology·Hiang Keat TanJason Pik Eu Chang
Jul 6, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Joonho JeongNeung Hwa Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.