PMID: 11927441Apr 3, 2002Paper

Effects of viscoelastic injection into Schlemm's canal in primate and human eyes: potential relevance to viscocanalostomy

Ophthalmology
Barbara A Smit, Murray A Johnstone

Abstract

To study possible initial mechanisms of alterations in aqueous outflow that may result from the injection of viscoelastic into Schlemm's canal (SC) during viscocanalostomy. Experimental animal (Macaca nemestrina) and human autopsy study. Eyes were dissected into a limbal ring and hemisected or quartered. Uncannulated segments served as controls. In treated segments, SC was cannulated and viscoelastic injected. Segments were fixed and sectioned into continuous 500 to 1000 microm pieces, examined at the dissecting microscope, and photomicrographs were taken. Representative tissue was further prepared for scanning electron microscopy or sectioned at 1 microm. Tissue sections were examined to determine the extent of dilation and disruption of SC and related structures. SC dimensions were measured in segments from controls, cannulated regions, and regions of viscoelastic injection beyond the cannula insertion. In the hemisected segments, the circumferential extent of SC dilation was determined, and structures within the canal were described and counted. SC was dilated with increased anteroposterior length and height in cannulated and viscoelastic-injected segments in both primate and human eyes relative to untreated controls. The wa...Continue Reading

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Citations

Jun 11, 2008·Archives of Ophthalmology·Sanjay AsraniJoseph Izatt
Dec 18, 2010·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M MatthaeiM Klemm
May 30, 2009·International Ophthalmology·Mehmet Numan AlpGulcan Kural
Jun 19, 2004·The British Journal of Ophthalmology·T ShaarawyI O Haefliger
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