PMID: 6967836Sep 1, 1980Paper

Effects of vitamin D metabolites on cellular Ca2+ and on Ca transport in primary cultures of bone cells

Molecular and Cellular Endocrinology
Y EilamA Harell

Abstract

Both 1,25-dihydroxycholecalciferol (1,25(OH)2D3) and 24,25-dihydroxycholecalciferol (24,25(OH)2D3) exerted direct effects on Ca2+ transport and accumulation in primary cultures of bone cells. The following changes were recorded. (1) A significant decrease in the amount of intracellular exchangeable Ca2+. (2) A marked increase in the rate constants of efflux from the 'slow'-turnover intracellular Ca pool. (3) A marked increase in the 'initial rate' of Ca influx into the cells. Thus, vitamin D metabolites caused an increase in the turnover of Ca2+ in bone cells and altered the steady-stae level of intracellular exchangeable Ca2+. Whereas the changes in the rate of efflux were abolished in the presence of inhibitors of protein synthesis, the increase in the rate of influx was not sensitive to these inhibitors. It is suggested that the changes in the two fluxes were mediated by different mechanisms and that the changes in influx were due to a direct effect of vitamin D metabolites on the cellular membranes.

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Citations

May 1, 1992·Journal of Cellular Biochemistry·A R de Boland, I Nemere
Oct 1, 1987·Calcified Tissue International·Y S KimR Miller
Aug 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J Stewart, P H Stern
Jan 1, 1981·Annals of the New York Academy of Sciences·M R HausslerL J Deftos
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K OhtaH Miyashita
Aug 15, 1998·Biochemical and Biophysical Research Communications·I Nemere, M C Farach-Carson
Jan 1, 1992·Bone·K ImaiS Saito
May 1, 1989·Toxicology and Applied Pharmacology·J F Rosen, J G Pounds

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