Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial

Medical Journal of the Islamic Republic of Iran
Alireza MirzaeiSalman Ghaffari

Abstract

Background: Numerous studies have been conducted to evaluate the frequency of hypovitaminosis D in patients with fibromyalgia syndrome (FMS) and its association with FMS symptoms. This study aimed at assessing the effect of hypovitaminosis D on the symptoms and quality of life of patients with fibromyalgia. Methods: A total of 74 FMS patients with hypovitaminosis D were randomly assigned into group A (Trazodone 25 mg at bedtime + vitamin D 50 000 IU weekly) and group B (Trazodone 25 mg at bedtime + placebo). Serum vitamin D level, Widespread Pain Index (WPI), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), and Short Form Health Survey (SF-36) were used at the beginning of the treatment and 4 and 8 weeks post treatment. Results: Significant improvements were observed in WPI, FIQ, and PSQI scores in both groups. Moreover, combination of vitamin D and Trazodone resulted in significant improvement of SF-36 scores compared to Trazodone therapy. Improvement in pain-related indices including the WPI and the physical component score (PCS) fraction of SF-36 was more noticeable in vitamin D/Trazodone combination therapy. Conclusion: This study suggests that vitamin D supplementation has significant therape...Continue Reading

Citations

Feb 6, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ryan S D'SouzaWenchun Qu
Feb 29, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Hyuk Joo LeeIn-Young Yoon
Aug 23, 2020·Nutrients·Giuditta PagliaiBarbara Colombini
Jan 15, 2021·Postgraduate Medical Journal·Vicky Chan, Kenneth Lo
Feb 11, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Matthew C MauckSamuel A McLean
Nov 30, 2019·Complementary Therapies in Clinical Practice·Karim HematiAlireza Mirzaei

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