Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats

BioMed Research International
Flávia Fernandes-LimaFrancisco J B Sampaio

Abstract

Vitamin D deficiency is common in pregnant women and infants. The present study aimed to investigate the effects of vitamin D restricted diet on the Wistar rats offspring penis morphology. Mother rats received either standard diet (SC) or vitamin D restricted (VitD) diet. At birth, offspring were divided into SC/SC (from SC mothers, fed with SC diet) and VitD/VitD (from VitD mothers, fed with VitD diet). After euthanasia the penises were processed for histomorphometric analysis. The VitD/VitD offspring displayed metabolic changes and reduction in the cross-sectional area of the penis, corpus cavernosum, tunica albuginea, and increased area of the corpus spongiosum. The connective tissue, smooth muscle, and cell proliferation percentages were greater in the corpus cavernosum and corpus spongiosum in the VitD/VitD offspring. The percentages of sinusoidal spaces and elastic fibers in the corpus cavernosum decreased. The elastic fibers in the tunica albuginea of the corpus spongiosum in the VitD/VitD offspring were reduced. Vitamin D restriction during perinatal and postnatal periods induced metabolic and structural changes and represented important risk factors for erectile dysfunction in the penis of the adult offspring. These fi...Continue Reading

References

Nov 1, 1990·The Journal of Urology·A M Goldstein, H Padma-Nathan
Mar 1, 1996·Journal of the American College of Cardiology·S B WilliamsM A Creager
May 22, 2002·JAMA : the Journal of the American Medical Association·Joshua A BeckmanPeter Libby
Apr 25, 2003·Neuroscience·D EylesF Feron
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Feb 14, 2006·BJU International·Waldemar S CostaFrancisco J B Sampaio
Apr 8, 2006·Progress in Biophysics and Molecular Biology·Armin Zittermann
Oct 25, 2007·Biochemical Society Transactions·D Susic
Oct 30, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Noori MakaM Jane Black
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ian P LuttrellKanchan Chitaley
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Oct 23, 2009·American Journal of Obstetrics and Gynecology·Megan L MulliganCarlos Bernal-Mizrachi
Dec 8, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Songcang ChenDavid G Gardner
Feb 23, 2010·Human Reproduction·Martin Blomberg JensenHenrik Leffers
Dec 15, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S PilzA Zittermann
Jun 1, 2011·The American Journal of Cardiology·David R MeldrumLouis J Ignarro
Jul 2, 2011·Journal of the American College of Cardiology·Ibhar Al MheidArshed A Quyyumi
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark R HausslerAnthony W Norman
Jan 10, 2012·Clinical Endocrinology·Katharina NimptschEdward Giovannucci
Jan 14, 2012·Current Opinion in Nephrology and Hypertension·Kenia Pedrosa NunesR Clinton Webb
Aug 29, 2012·PloS One·Fernanda A M NascimentoCarlos A Mandarim-de-Lacerda
Aug 29, 2012·Dermato-endocrinology·Marc Sorenson, William B Grant
Feb 15, 2013·The Journal of Clinical Endocrinology and Metabolism·A J van BallegooijenI A Brouwer
Jun 4, 2013·Urology·Mohamed E MostafaTaymour Mostafa
Jul 26, 2013·Journal of Nutritional Science and Vitaminology·Kazuhiro YamadaTetsunori Kawata
Nov 29, 2013·Molecular Endocrinology·Olena AndrukhovaReinhold G Erben
Jun 18, 2014·The Journal of Clinical Endocrinology and Metabolism·D HoferB Obermayer-Pietsch
Aug 6, 2014·The Journal of Sexual Medicine·Alessandra BarassiGian Vico Melzi d'Eril
Sep 29, 2015·BioMed Research International·Bruno Felix-PatrícioFrancisco José Sampaio
Dec 10, 2015·The Journal of Sexual Medicine·Biljana MusickiArthur L Burnett
Dec 19, 2015·Scandinavian Journal of Immunology·I Szymczak, Rafal Pawliczak
Jan 14, 2016·Endocrine·Nicola CarettaCarlo Foresta
May 10, 2016·Global Journal of Health Science·Maryam AbbasianMehdi Raei
Jan 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Onder CanguvenAbdullah Al Naimi
Jul 19, 2017·Turkish Journal of Urology·Raidh A TalibÖnder Cangüven

❮ Previous
Next ❯

Citations

Feb 6, 2020·The World Journal of Men's Health·Onder Canguven, Ahmad H Al Malki
Sep 5, 2019·Andrologia·Halil Lutfi CanatHasan Anıl Atalay

❮ Previous
Next ❯

Methods Mentioned

BETA
Enzyme-Linked Immunosorbent Assay
glycosylation

Software Mentioned

ImageJ
ImageJ Image Processing and Analysis in Java
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.