Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients
Andrea MaugeriAntonella Agodi

Abstract

During pregnancy, vitamin D supplementation may be a feasible strategy to help prevent low birthweight (LBW) and small for gestational age (SGA) births. However, evidence from randomized controlled trials (RCTs) is inconclusive, probably due to heterogeneity in study design and type of intervention. A systematic literature search in the PubMed-Medline, EMBASE, and Cochrane Central Register of Controlled Trials databases was carried out to evaluate the effects of oral vitamin D supplementation during pregnancy on birthweight, birth length, head circumference, LBW, and SGA. The fixed-effects or random-effects models were used to calculate mean difference (MD), risk ratio (RR), and 95% Confidence Interval (CI). On a total of 13 RCTs, maternal vitamin D supplementation had a positive effect on birthweight (12 RCTs; MD = 103.17 g, 95% CI 62.29⁻144.04 g), length (6 RCTs; MD = 0.22 cm, 95% CI 0.11⁻0.33 cm), and head circumference (6 RCTs; MD:0.19 cm, 95% CI 0.13⁻0.24 cm). In line with these findings, we also demonstrated that maternal vitamin D supplementation reduced the risk of LBW (3 RCTs; RR = 0.40, 95% CI 0.22⁻0.74) and SGA (5 RCTS; RR = 0.69, 95% CI 0.51⁻0.92). The present systematic review and meta-analysis confirmed the well-e...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 16, 1999·Statistics in Medicine·S G Thompson, S J Sharp
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Dec 25, 2002·The American Journal of Clinical Nutrition·Robert P HeaneyM Janet Barger-Lux
Jun 29, 2004·Journal of the Society for Gynecologic Investigation·Katie N EvansMartin Hewison
Jul 11, 2006·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Sep 9, 2006·The American Journal of Clinical Nutrition·Marjolein VisserPaul Lips
Jan 20, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Anthony W NormanPaul Lips
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jan 24, 2008·Reproductive Biology and Endocrinology : RB&E·David BarreraLorenza Díaz
Sep 6, 2008·Clinical Endocrinology·C K H YuS Robinson
Jun 22, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Helen L HenryPeter R Ebeling
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Mar 19, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Michael F Holick
Apr 16, 2011·Public Health Nutrition·A Catharine Ross
Jun 28, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce W HollisCarol L Wagner
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Andrew Thorne-Lyman, Wafaie W Fawzi
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Usha RamakrishnanReynaldo Martorell
Mar 27, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christopher S Kovacs
Jul 16, 2014·Health Technology Assessment : HTA·Nicholas C HarveyCyrus Cooper
Feb 17, 2015·Clinical Endocrinology·Aanchal SablokHarish Chellani
Mar 31, 2015·Journal of Caring Sciences·Sakineh Mohammad-Alizadeh-CharandabiFarzane Khodabande
Mar 5, 2016·European Journal of Clinical Nutrition·S KarrasD G Goulis
Mar 11, 2016·Advanced Biomedical Research·Elham Naghshineh, Somaiyh Sheikhaliyan
Apr 15, 2016·International Journal of Preventive Medicine·Zatollah AsemiAhmad Esmaillzadeh
Jun 30, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Luz Maria De-RegilJuan Pablo Peña-Rosas
Feb 6, 2017·The Journal of Obstetrics and Gynaecology Research·Shan-Shan ZhouFang-Biao Tao

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Citations

Aug 5, 2020·Critical Reviews in Food Science and Nutrition·Rui ZhaoLiping Hao
Aug 24, 2019·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg, Sabrina Pillai
Nov 25, 2020·Annals of Nutrition & Metabolism·Carol L Wagner, Bruce W Hollis

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Methods Mentioned

BETA
SGA

Software Mentioned

RevMan
Review Manager
Comprehensive Meta - analysis

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