Effects of Vitamin D Supplementation in Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

International Journal of Preventive Medicine
Mahsa JaliliAzita Hekmatdoost

Abstract

There are some evidence that Vitamin D supplementation may be beneficial for patients with irritable bowel syndrome (IBS). The aim of this study was to evaluate the effects of Vitamin D supplementation on symptoms and quality of life (QOL) in patients with IBS. In a randomized, double-blind, placebo-controlled clinical trial, 116 patients with IBS were supplemented weekly with either a pearl of 50,000 IU Vitamin D or an identical pearl of placebo containing medium chain triglyceride for 6 weeks. Mean age of patients was 42.24 ± 12.26, and 40.06 ± 13.37 in Vitamin D and placebo groups, respectively. Dietary intakes were similar between and within groups. Serum concentration of 25-hydroxy Vitamin D increased significantly from 21.10 ± 5.23 to 36.43 ± 12.34 in the Vitamin D group (P < 0.001), while it was not significantly different before and after the trial in placebo group. The IBS symptoms severity scores (SSSs), disease-specific QOL, and total score were evaluated at weeks 0 and 6. IBS-SSS, IBS-QOL, and the total score were improved significantly more in Vitamin D group in comparison to the placebo group (P < 0.05). This study indicates that Vitamin D therapy can improve the severity of symptoms and QOL in patients with IBS; ...Continue Reading

References

Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Juan KongYan Chun Li
Dec 1, 2010·Annals of the New York Academy of Sciences·Margherita T Cantorna
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Nov 15, 2011·Molecular Aspects of Medicine·Jot Hui OoiMargherita T Cantorna
May 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S LudidiA A M Masclee
Mar 29, 2014·Experimental Biology and Medicine·Margherita T CantornaJamaal James
Oct 22, 2014·The British Journal of Nutrition·Shalbha TiwariSurya Kumar Singh
Mar 4, 2015·JAMA : the Journal of the American Medical Association·William D CheyShanti Eswaran
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Carla E FlikNiek J de Wit
May 12, 2015·Oman Medical Journal·Yasir Khayyat, Suzan Attar
Jul 28, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Caroline S StokesFrank Lammert
Dec 19, 2015·Physiological Research·M BičíkováL Stárka
Jan 1, 2016·Current Rheumatology Reviews·Michael D CashmanSrinivas R Puli
Jan 18, 2016·BMC Musculoskeletal Disorders·Paul S McCabeUNKNOWN EMAS Study Group
Jan 27, 2016·World Journal of Gastroenterology : WJG·Stacey MeekerJisun Paik
May 8, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A AbbasnezhadA Ghadiri
Jul 7, 2016·Indian Journal of Clinical Biochemistry : IJCB·Praveen Sharma, Prasenjit Mitra

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
Doaa El AmrousyHossam Hodeib
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Amir AbbasnezhadA Ghadiri
Journal of Neurogastroenterology and Motility
Yong Sung KimIBS Club of the Korean Society of Neurogastroenterology and Motility
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Guillaume Pineton de ChambrunPierre Desreumaux
© 2022 Meta ULC. All rights reserved