Effects of vitamin D supplementation on blood pressure

Southern Medical Journal
Sheng Hui WuLiu Zhong

Abstract

Inconsistent findings from epidemiological studies have continued the controversy over the role of oral vitamin D supplementation in reducing blood pressure in normotensive or hypertensive populations. We performed a literature search up to December 2009, with no restrictions. Only double-blind randomized controlled trials (RCTs) of oral vitamin D supplementation in normotensive or hypertensive individuals with blood pressure measurements were included. From 244 retrieved papers, four RCTs involving 429 participants met our inclusion criteria for this meta-analysis. Vitamin D supplementation reduced systolic blood pressure (SBP) by 2.44 mm Hg (weighted mean difference [WMD]: -2.44, 95% confidence interval [CI]: -4.86, -0.02), but not diastolic blood pressure (DBP) (WMD: -0.02, 95% CI: -4.04, 4.01) compared with calcium or placebo. Subgroup analysis suggested that the change of blood pressure did not vary markedly across the dose of vitamin D supplementation, study length, or intervention. Oral vitamin D supplementation may lead to a reduction in systolic blood pressure but not diastolic blood pressure. Given the small number of trials and small but statistically significant reduction in systolic blood pressure from this meta-an...Continue Reading

References

Feb 1, 1995·JAMA : the Journal of the American Medical Association·K F SchulzD G Altman
Jan 1, 1993·Statistical Methods in Medical Research·J L Fleiss
Apr 3, 1996·JAMA : the Journal of the American Medical Association·H C BucherD L Hunt
Mar 1, 1997·Diabetologia·K C BaynesD Kromhout
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 17, 2001·Asia Pacific Journal of Clinical Nutrition·G L Khor
May 25, 2002·Public Health Nutrition·H H Vorster
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 10, 2003·Journal of Cellular Biochemistry·Yan Chun Li
Apr 29, 2004·The American Journal of Clinical Nutrition·Ken C ChiuMohammed F Saad
Aug 12, 2005·Journal of Hypertension·Rolf JordeJohan Sundsfjord
Apr 8, 2006·Progress in Biophysics and Molecular Biology·Armin Zittermann
Oct 14, 2006·BMC Medical Research Methodology·Leon BaxKarel G M Moons
Mar 21, 2007·Hypertension·John P FormanGary C Curhan
Sep 12, 2007·BMC Medical Research Methodology·Leon BaxKarel G M Moons
Jul 26, 2008·Nutrition·Kamilia TaiIan M Chapman
Oct 1, 2008·Hypertension·Karen L MargolisUNKNOWN Women's Health Initiative Investigators
Jul 10, 2009·Journal of Hypertension·Miles D WithamAllan D Struthers

❮ Previous
Next ❯

Citations

Mar 8, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A Beveridge, M D Witham
Mar 30, 2012·Current Hypertension Reports·Shweta R Motiwala, Thomas J Wang
Jul 14, 2012·Age and Ageing·Kevin Gerald McCarrollConal Cunningham
Jun 12, 2013·European Heart Journal·Ibhar Al MheidArshed A Quyyumi
Apr 27, 2011·Current Opinion in Nephrology and Hypertension·Shweta R Motiwala, Thomas J Wang
Jul 24, 2012·Current Opinion in Nephrology and Hypertension·Hector Tamez, Ravi I Thadhani
Jan 10, 2013·Current Opinion in Nephrology and Hypertension·Hector TamezRavi I Thadhani
Jul 14, 2010·Southern Medical Journal·Thomas F Heston
Jun 13, 2014·PloS One·Priscila Portugal Dos SantosSergio Alberto Rupp de Paiva
Jul 15, 2015·Expert Review of Cardiovascular Therapy·Louise A Beveridge, Miles D Witham
Jan 16, 2016·Evidence-based Mental Health·Mathew ChiangXiaoduo Fan
Aug 11, 2012·Endocrinology and Metabolism Clinics of North America·Heidi Wolden-KirkChantal Mathieu
Jun 2, 2012·Journal of Chiropractic Medicine·Ralph A Kruse, Jerrilyn A Cambron
Jun 21, 2011·Biotechnology Advances·Rune LarsenEdel O Elvevoll
Oct 1, 2015·Journal of the American Society of Hypertension : JASH·Songcang ChenDevendra K Agrawal
Jun 21, 2011·Clinical Endocrinology·Stefan PilzJacqueline M Dekker
Nov 5, 2011·The Journal of Clinical Hypertension·Kevin J Woolf, John D Bisognano
Jun 9, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anna S ChallaEkaterini C Siomou
Mar 31, 2015·Diabetes & Metabolic Syndrome·Priyanka Prasad, Anita Kochhar
Apr 24, 2013·Nature Reviews. Nephrology·Sujana S GuntaRobert H Mak
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bokyung Min
Mar 4, 2017·Journal of the American Society of Nephrology : JASN·Tianxin Yang, Chuanming Xu
Dec 19, 2015·Physiological Reviews·Sylvia ChristakosGeert Carmeliet
Oct 19, 2017·Electrolyte & Blood Pressure : E & BP·Hye Yun JeongSo-Young Lee
Oct 31, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gurpreet KaurJuhi Kumar
Oct 1, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kemal Atasayan, Tevfik Yoldemir
Nov 26, 2010·Expert Review of Cardiovascular Therapy·Stefan Pilz, Andreas Tomaschitz
Mar 19, 2020·Anais Da Academia Brasileira De Ciências·Maria DA Conceição R GonçalvesAlexandre S Silva
Aug 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Bouillon
Jul 25, 2019·Current Pharmaceutical Design·Ana Valer-MartinezMaira Bes-Rastrollo
Mar 27, 2020·International Journal of General Medicine·Farahnaz JoukarFariborz Mansour-Ghanaei
Nov 30, 2016·Journal of Nutrition in Gerontology and Geriatrics·Jaime Alberto Bricio-BarriosCarmen Alicia Sanchez-Ramirez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.