Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
P TuncelR Tokyay

Abstract

To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1978·Agents and Actions·A C AllisonH U Schorlemmer
Nov 1, 1992·The American Review of Respiratory Disease·R DemlingJ Knox
Apr 1, 1992·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A DwengerU Lehmann
Apr 1, 1990·The Journal of Trauma·C H FangG D Warden
Aug 1, 1989·Environmental Research·A A KamalA S Hammad
Dec 1, 1989·Journal of Applied Physiology·T A HazinskiT N Hansen
May 1, 1989·The American Review of Respiratory Disease·R Demling, C LaLonde
Dec 17, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G W BurtonK U Ingold
Jan 1, 1985·Annual Review of Nutrition·P B McCay
Nov 1, 1985·Gastroenterology·M J ArthurR Wright
Apr 15, 1986·The Biochemical Journal·K H CheesemanK U Ingold
Sep 1, 1988·Journal of Applied Physiology·A SeekampR Demling
Jul 1, 1987·Chemistry and Physics of Lipids·E Niki
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L TribbleD P Jones
Jan 1, 1985·Molecular Aspects of Medicine·B Halliwell, J M Gutteridge
Jan 1, 1984·Methods in Enzymology·R O Recknagel, E A Glende

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