Effects of vitamin E and vitamin B2 on chromate-induced DNA lesions

Biological Trace Element Research
M Sugiyama

Abstract

The induction of DNA single strand breaks by carcinogenic chromate compounds has been found to be altered by vitamin E and vitamin B2. Pretreatment with vitamin E for 24 h prior to exposure to Na2CrO4 resulted in a decrease of chromate-induced DNA single strand breaks, whereas similar treatment with vitamin B2 enhanced levels of breaks induced by chromate. In contrast, levels of DNA protein crosslinks, the other major lesion induced, were not affected by vitamin E or vitamin B2. The uptake of Na2CrO4 was not affected by pretreatment with these vitamins. The role of vitamins in chromate-induced DNA damages is discussed.

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Citations

Jul 1, 1991·Biological Trace Element Research·M SugiyamaM Yamamoto
Jan 1, 1992·Free Radical Biology & Medicine·M Sugiyama
Feb 3, 2000·Free Radical Biology & Medicine·W A Pryor
Oct 31, 2001·Nutrition·P A LachanceW S Jeong
May 1, 1991·Environmental Health Perspectives·M Sugiyama
Jan 1, 1993·Critical Reviews in Toxicology·M D CohenM Costa
May 1, 2010·Chemico-biological Interactions·Kristen P NickensSusan Ceryak
Aug 15, 2006·Mutation Research·Eliza Grlickova-DuzevikJohn Pierce Wise
Sep 1, 1991·Photochemistry and Photobiology·K MatsumotoR Ogura
Sep 23, 2010·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·A ChiuL Donehower

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