Effects of vitamin e on bone biomechanical and histomorphometric parameters in ovariectomized rats

Journal of Osteoporosis
Rafaela G FeresinB H Arjmandi

Abstract

The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n = 12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD of vitamin E had increased serum alkaline phosphatase compared to the Ovx-control group. Bone histomorphometry analysis indicated a decrease in bone resorption as well as increased bone formation and mineralization in the Ovx groups supplemented with MD and HD of vitamin E. Microcomputed tomography findings indicated no effects of vitamin E on trabecular bone of fifth lumbar vertebrae. Animals receiving HD of vitamin E had enhanced fourth lumbar vertebra quality as evidenced by improved ultimate and yield load and stress when compared to Ovx-control group. These findings demonstrate that vitamin E improves bone quality, attenuates bone resorption, and enhances the rate of bone formation while being unable to restore bone density and trabec...Continue Reading

References

Sep 1, 1990·The American Journal of Clinical Nutrition·S N MeydaniJ B Blumberg
Mar 1, 1990·The Journal of Clinical Investigation·I R GarrettG R Mundy
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Dec 1, 1985·American Journal of Obstetrics and Gynecology·R D WasnichJ M Vogel
Jan 1, 1984·Medical Hypotheses·E J Crary, M F McCarty
Oct 1, 1995·Acta Orthopaedica Scandinavica·E GöktürkZ Gülbas
Feb 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·I JialalB A Huet
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Sep 1, 1993·Journal of the American Dietetic Association·G M Wardlaw
Oct 1, 1995·Calcified Tissue International·H XuM F Seifert
Jan 1, 1996·Annual Review of Nutrition·M G Traber, H Sies
Sep 1, 1996·The Journal of International Medical Research·K DurakK Turan
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H MelhusS Ljunghall
Jun 27, 2000·The Journal of Nutrition·A AzziJ M Zingg
Jun 30, 2000·Human Reproduction·C SternL W Chamley
Aug 29, 2000·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M NorazlinaB A Khalid
Feb 13, 2001·The Journal of Nutrition·M Meydani
Feb 13, 2001·The Journal of Nutrition·D WuS Meydani
Feb 13, 2001·The Journal of Nutrition·I JialalN Kaul
Jul 17, 2001·Immunology·R J van't Hof, S H Ralston
Oct 12, 2001·Biochemical and Biophysical Research Communications·S BasuH Melhus
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R RicciarelliA Azzi
Dec 18, 2001·BMJ : British Medical Journal·J M Dixon
Jun 22, 2002·Lancet·Pierre D Delmas
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Robert Marcus
Sep 17, 2002·The Journal of Nutritional Biochemistry·Bahram ArjmandiSimin Meydani
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M P AkhterR R Recker
Aug 2, 2003·Aging Clinical and Experimental Research·Dennis R TaaffeTamara B Harris
Aug 5, 2003·Journal of the American College of Nutrition·Anand Dutta, Sudhir K Dutta
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karim AsehnouneEdward Abraham
Oct 2, 2004·The Journal of International Medical Research·Cy TurkS Muhtaroglu
Mar 3, 2005·Calcified Tissue International·B J SmithB H Arjmandi

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Citations

Apr 15, 2014·Nutrients·Kok-Yong Chin, Soelaiman Ima-Nirwana
Dec 27, 2015·Pharmacology & Therapeutics·Hong Yong PehW S Fred Wong
Oct 26, 2018·Calcified Tissue International·Mackenzie L HaganMeghan E McGee-Lawrence
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ahmad Nazrun ShuidIsa Naina Mohamed
Nov 1, 2017·Menopause : the Journal of the North American Menopause Society·Shirin PourafsharBahram H Arjmandi
Oct 26, 2018·PloS One·Sheau C ChaiBahram H Arjmandi
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Maryam TorshabiElahe Karami
Mar 27, 2019·International Journal of Molecular Sciences·Sok Kuan WongSoelaiman Ima-Nirwana
Nov 13, 2020·Reports of Biochemistry & Molecular Biology·Hoda MoghazyHekmat Osman Abdel Aziz

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