Effects of vitamins E and C combined with β-carotene on cognitive function in the elderly

Experimental and Therapeutic Medicine
Yonghua LiY U Zhou

Abstract

The aim of the present study was to investigate the effect of vitamins E (VE) and C (VC), combined with β-carotene (β-C), on cognitive function in the elderly. A total of 276 elderly subjects completed the prospective study following treatment with VE, VC and different doses of β-C or with VE only. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale (HDS) tests. The plasma levels of amyloid-β (Aβ) and estradiol (E2) were determined by radioimmunoassay (RIA). Results from the MMSE and HDS assessments indicated that the treatment strategy of VE and VC combined with β-C significantly improved cognitive function in the elderly subjects, particularly with higher doses of β-C. Furthermore, RIA suggested that treatment with these vitamins could markedly reduce plasma Aβ levels and elevate plasma E2 levels. The present findings suggest that treatment with VE, VC and β-C results in promising improvements in cognitive function in the elderly.

References

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Citations

Aug 27, 2015·Marine Drugs·Montserrat Rodrigo-BañosRosa María Martínez-Espinosa
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Anne Ws RutjesJenny McCleery
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Apr 19, 2017·The Cochrane Database of Systematic Reviews·Nicolas FarinaNaji Tabet

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