Effects of volatile anesthetic isoflurane on ATP-sensitive K+ channels in rabbit ventricular myocytes

Biochemical and Biophysical Research Communications
J HanY E Earm

Abstract

It has been suggested that volatile anesthetic, isoflurane mediates cardioprotective effects via activation of the ATP-sensitive K+ (KATP) channels. However, no direct evidence has been provided to define whether isoflurane activates cardiac KATP channels using patch-clamp technique. We examined the effects of isoflurane on the KATP channels in rabbit ventricular myocytes by use of patch-clamp technique. Contrary to the results of the in vivo experiments, isoflurane inhibited the channel activity without a change in the single-channel conductance. Isoflurane decreased the channel activity by a decrease in burst duration and an increase in the inter-burst duration. On the other hand, isoflurane diminished the ATP sensitivity of KATP channels, indicating an increased probability of KATP channel opening for a given concentration of ATP after isoflurane anesthesia. The result supports, at least in part, the hypothesis that isoflurane mediates cardioprotective effects via KATP channel activation.

Citations

Apr 3, 2001·The Journal of Physiology·I SeckinY S Prakash
Jun 1, 2005·Vascular Pharmacology·Martin W BienengraeberDavid C Warltier
Sep 25, 2003·British Journal of Anaesthesia·M ZauggM C Schaub
Jul 20, 2002·Anesthesiology·Kazuhiro FujimotoWai-Meng Kwok
Mar 17, 1999·Anesthesiology·M S IsmaeilB A Cason
Apr 28, 2004·Anesthesiology·Katsuya TanakaDavid C Warltier
Aug 27, 2013·Journal of the American Heart Association·Anlong LiColin G Nichols
Apr 27, 2007·Journal of Anesthesia·Anna StadnickaZeljko J Bosnjak
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Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hemal H PatelGarrett J Gross

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