PMID: 35042Feb 1, 1979

Effects of volatile anesthetics on directly and indirectly stimulated skeletal muscle

B E Waud, D R Waud


Isolated guinea pig nerve-lumbrical muscle preparations were exposed to halothane, methoxyflurane, isoflurane, enflurane, fluroxene, and diethyl ether. The temporal courses of the effects on indirectly and directly elicited twitch responses were determined over a range of concentrations for each agent. When the anesthetics were compared at concentrations equivalent in terms of minimum alveolar concentration (MAC), a spectrum was observed in which halothane, methoxyflurane and isoflurane depressed the indirect twitch response at 3.5--5 MAC and the direct twitch response at 8--10 MAC. Diethyl ether and fluroxene depressed the indirect twitch response at 2--3.5 MAC and the direct twitch response at 3--6 MAC. Enflurane depressed the indirect response at 1.5--2.5 MAC and the direct response at 6--8 MAC. When the anesthetics were compared at concentrations equivalent in terms of their abilities to depress end-plate depolarization, however, all anesthetics were equipotent. Depression of the indirect twitch response occurred only when anesthetic concentrations were great enough to depress depolarization by 50 per cent.


Dec 1, 1984·Pflügers Archiv : European journal of physiology·S KuriharaT Sakai
Jan 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T IdeT Mizuguchi
May 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E ReidA H Hayes
Jul 1, 1990·Journal of Anesthesia·T KochiT Mizuguchi
Oct 1, 1990·Journal of Anesthesia·Y IzumiT Mizuguchi
Jul 1, 1991·Journal of Anesthesia·T KochiT Mizuguchi
Apr 1, 1993·Acta Anaesthesiologica Scandinavica·T IdeT Mizuguchi
May 1, 1996·Anesthesiology·B M TavernierH Reyford
Nov 30, 2000·British Journal of Anaesthesia·T SuzukiS Ogawa
Sep 24, 2005·Paediatric Anaesthesia·Necmiye HadimiogluMeliha Erman

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