Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells

The Journal of Nutritional Biochemistry
Angelo De MartinoGiuseppe Rotilio

Abstract

Garlic extracts, either aqueous or oily, are commonly employed to prepare garlic derivative supplements used as nutraceuticals for the treatment of different pathologies. In this study, we investigated the effects of water garlic extracts from two different areas of Italy well known for garlic production, Latina (GEL) and Sulmona (GES), on cell cycle and death of HepG2 hepatoma cells. The effects of the treatments with GEL and GES were also compared with the oil-soluble sulfur compound of garlic, diallyl disulfide (DADS). GEL and GES induced a p53/p21-dependent cell cycle arrest in G2/M phase and apoptosis, although to a different extent, whereas DADS, under the experimental conditions used, was not detrimental to HepG2 cells. GEL and GES committed HepG2 cells to apoptosis by the activation of c-Jun-NH(2) terminal kinase (JNK)/c-Jun phosphorylative cascade without a detectable increase in the flux of reactive oxygen species. Moreover, differentiation of HepG2 cells induced by retinoic acid determined resistance to GEL and GES treatments without the activation of JNK signaling pathway. Overall, the results obtained indicate that water-soluble garlic extracts are more inhibitory of the growth of transformed hepatoma cells than th...Continue Reading

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Citations

Nov 10, 2007·Urology·Carlotta GaleoneCarlo La Vecchia
May 6, 2015·The Journal of Nutritional Biochemistry·Chun-Hao HuangShyh-Horng Chiou
Nov 18, 2008·Journal of Pineal Research·Javier Martín-RenedoJavier González-Gallego
May 19, 2012·Acta Biochimica Et Biophysica Sinica·Wenjun LiFei Gao
Apr 20, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H LingQ Su
May 20, 2017·Nutrition and Cancer·Majid Tafrihi, Roohollah Nakhaei Sistani
Mar 26, 2014·Food & Function·Phoebe Zapanta TrioDe-Xing Hou
Dec 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Christopher D MannDavid P Berry
Aug 30, 2019·Phytotherapy Research : PTR·Yahya AsemaniZahra Amirghofran
Apr 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Saleh A AlmatroodiArshad H Rahmani
Aug 17, 2021·Nutrition and Cancer·Deepa S Mandlik, Satish K Mandlik
May 22, 2008·Journal of Agricultural and Food Chemistry·Huajia LiQiuhui Hu

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