Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women.

Journal of Lipid Research
Bela F AsztalosPeter J Havel

Abstract

Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, alpha-1 and alpha-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and prebeta-1 levels were observed with significant increases of HDL-C and alpha-1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) ...Continue Reading

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Citations

Nov 1, 2011·Obesity Surgery·Ignacio Garcia-MarirrodrigaJuan Ybarra
Feb 16, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H E Wilson-PérezR J Seeley
May 4, 2011·Current Opinion in Lipidology·Bela F AsztalosErnst J Schaefer
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Nov 29, 2013·Journal of Obesity·Khalid Al KhalifaClaudio Violato
Apr 19, 2015·Lipids in Health and Disease·Jin Won LeeKyo Young Song
Oct 25, 2014·Journal of Atherosclerosis and Thrombosis·Shigetsugu TsujiMasakazu Yamagishi
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Nov 12, 2015·World Journal of Gastroenterology : WJG·David BenaigesJuana A Flores-Le Roux

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