Abstract
The growing epidemics of obesity and asthma are major public health concerns. Although asthma-obesity links are widely studied, the effects of weight loss on asthma severity measured by airway hyperresponsiveness (AHR) have received limited attention. The main study objective was to examine whether weight reduction reduces asthma severity in obese adults with asthma. In a prospective, controlled, parallel-group study, we followed 22 obese participants with asthma aged 18 to 75 years with a BMI ≥ 32.5 kg/m2 and AHR (provocative concentration of methacholine causing a 20% fall in FEV1 [PC20] < 16 mg/mL). Sixteen participants followed a behavioral weight reduction program for 3 months, and six served as control subjects. The primary outcome was change in AHR over 3 months. Changes in lung function, asthma control, and quality of life were secondary outcomes. At study entry, participant mean ± SD age was 44 ± 9 years, 95% were women, and mean BMI was 45.7 ± 9.2 kg/m2. After 3 months, mean weight loss was 16.5 ± 9.9 kg in the intervention group, and the control group had a mean weight gain of 0.6 ± 2.6 kg. There were significant improvements in PC20 (P = .009), FEV1 (P = .009), FVC (P = .010), asthma control (P < .001), and asthma q...Continue Reading
References
May 20, 1999·Chest·E F JuniperD R King
Nov 26, 1999·The European Respiratory Journal·E F JuniperD R King
Mar 24, 2000·BMJ : British Medical Journal·B Stenius-AarnialaP Mustajoki
Feb 1, 1993·Obesity Surgery·A M Macgregor, R A Greenberg
Nov 18, 2000·Chest·K HakalaA Sovijärvi
Sep 12, 2006·Chest·Li-Ying WangBrydon J B Grant
Nov 24, 2006·Thorax·Rafea ShaabanMahmoud Zureik
Feb 13, 2007·Free Radical Biology & Medicine·James B JohnsonMark P Mattson
Feb 15, 2007·Allergy·M DockrellE Valovirta
Sep 14, 2007·Respiratory Medicine·Mauro ManiscalcoMatteo Sofia
Jul 30, 2008·Thorax·I U EneliC A Camargo
Nov 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shawn D AaronUNKNOWN Canadian Respiratory Clinical Research Consortium
Jul 4, 2009·The Spine Journal : Official Journal of the North American Spine Society·Carolyn E Schwartz, Joel A Finkelstein
Jan 16, 2010·The European Respiratory Journal·V HjellvikK Furu
Feb 16, 2010·Chest·Smita PakhaleShawn D Aaron
Jun 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Sat SharmaMary Cheang
Sep 17, 2010·Proceedings of the American Thoracic Society·Anne E DixonUNKNOWN American Thoracic Society Ad Hoc Subcommittee on Obesity and Lung Disease
Jul 26, 2011·The Journal of Allergy and Clinical Immunology·Anne E DixonCharles G Irvin
Feb 14, 2012·Respiratory Medicine·Louis-Philippe BouletPaul Poirier
Jan 3, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H A ScottL G Wood
Jun 14, 2013·BMC Pulmonary Medicine·Smita PakhaleLucy Turner
Jul 13, 2013·Sports Medicine·Philipp A EichenbergerChristina M Spengler
Aug 24, 2013·Journal of Allergy·Bill Brashier, Sundeep Salvi
Sep 7, 2013·International Journal of Epidemiology·Ben Michael BrumptonXiao-Mei Mai
Nov 16, 2013·The European Respiratory Journal·Sérvulo Azevedo Dias-JúniorAlberto Cukier
Apr 11, 2014·Experimental Biology and Medicine·Sveta MohananMichael Dulin
Jun 2, 2014·Lancet·Marie NgEmmanuela Gakidou
Citations
Apr 14, 2016·Allergo Journal International·Marek Lommatzsch, Paul Stoll
May 24, 2016·Mediators of Inflammation·Hannu KankaanrantaPinja Ilmarinen
Apr 8, 2016·Current Opinion in Allergy and Clinical Immunology·Catherine B Charron, Smita Pakhalé
Jul 14, 2016·Multidisciplinary Respiratory Medicine·Thiago Thomaz MafortAgnaldo José Lopes
Jun 11, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Joshua GoodShilpa Dogra
Jan 13, 2016·American Journal of Respiratory Cell and Molecular Biology·Hye Jung ParkJung-Won Park
Apr 12, 2016·American Journal of Respiratory Cell and Molecular Biology·Jennifer L AtherMatthew E Poynter
Oct 18, 2016·American Journal of Respiratory and Critical Care Medicine·Patricia D FreitasCelso R F Carvalho
Sep 28, 2016·Thorax·Dale T Umetsu
Feb 16, 2018·Frontiers in Pharmacology·Zeyu ZengWeixi Zhang
Nov 28, 2017·Allergy·T R Tay, M Hew
Jul 31, 2018·Expert Review of Respiratory Medicine·Anne E Dixon, Ubong Peters
Oct 27, 2018·Expert Review of Respiratory Medicine·Andreas A TeferraH Marike Boezen
Nov 28, 2018·Current Opinion in Allergy and Clinical Immunology·Helen Clare Ricketts, Douglas C Cowan
Mar 14, 2018·ERJ Open Research·Eleftherios ZervasMina Gaga
Feb 2, 2019·Diabetes Care·Liliana Gutiérrez-CarrasquillaAlbert Lecube
Jun 28, 2019·PloS One·Paula Duarte OliveiraAna Maria Baptista Menezes
Jul 17, 2019·Allergy·Eric SzeParameswaran Nair
Sep 12, 2019·Current Allergy and Asthma Reports·Arjun MohanNjira Lugogo
Oct 1, 2019·Annals of Internal Medicine·Melissa B King-Biggs
Dec 8, 2017·Respiratory Research·Marise J KasteleynChristian Taube
Sep 17, 2017·Scientific Reports·Young Bok LeeHiun Suk Chae
Oct 20, 2018·Surgical Endoscopy·Alfredo D GuerronDana Portenier
Jan 24, 2019·Scientific Reports·Haris YounasVsevolod Y Polotsky
Jun 27, 2019·Expert Review of Endocrinology & Metabolism·Aliva De, Deepa Rastogi
Oct 23, 2019·NPJ Primary Care Respiratory Medicine·Sabina StanescuBen Ainsworth
Dec 7, 2018·Journal of Applied Physiology·Aline Grandi SilvaCelso R F Carvalho
Aug 18, 2020·Journal of Asthma and Allergy·Helena PiteMário Morais-Almeida
Mar 26, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ümüş ÖzbeyZeynep Mısırlıgil
Feb 17, 2021·Obesity Surgery·Naveed HossainCynthia-Michelle Borg
Apr 9, 2018·The Journal of Allergy and Clinical Immunology·Ubong PetersErick Forno
Mar 28, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·José J Leija-MartínezFengyang Huang
Jul 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ryan C MurphyMatthew C Altman