Effects of weight loss on erythrocyte membrane composition and fluidity in overweight and moderately obese women

The Journal of Nutritional Biochemistry
R CazzolaBenvenuto Cestaro

Abstract

A previous study showed chemical and physical impairment of the erythrocyte membrane of overweight and moderately obese women. The present study investigated the effects of a low-calorie diet (800 kcal/day deficit for 8 weeks) on erythrocyte membrane properties in 70 overweight and moderately obese (body mass index, 25-33 kg/m(2)) normotensive, nondiabetic women. At the end of dietary intervention, 24.3% of women dropped out, 45.7% lost less than 5% of their initial weight (Group I) and only 30% of patients lost at least 5% of their initial body weight (Group II). Group I showed no significant changes in erythrocyte membrane composition and function. The erythrocyte membranes of Group II showed significant reductions in malondialdehyde, lipofuscin, cholesterol, sphingomyelin, palmitic acid and nervonic acid and an increase in di-homo-γ-linolenic acid, arachidonic acid and membrane fluidity. Moreover, Group II showed an improvement in total cholesterol, low-density lipoprotein cholesterol, glycemia and insulin resistance. These changes in erythrocyte membrane composition could reflect a virtuous cycle resulting from the reduction in insulin resistance associated with increased membrane fluidity that, in turn, results in a sequen...Continue Reading

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Citations

Feb 19, 2013·Metabolism: Clinical and Experimental·Roberta CazzolaBenvenuto Cestaro
Sep 23, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura J W KeppleyTodd E Fox
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta CazzolaBenvenuto Cestaro
May 24, 2020·Nutrients·Isabel E YoungHelen T O'Connor
Nov 18, 2018·Frontiers of Medicine·Xiaojiao ZhengWei Jia

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