Effects of weight loss on ventricular systolic and diastolic functions and left ventricular mass assessed by tissue doppler imaging in obese geriatric women: preliminary report

Aging Clinical and Experimental Research
Murat VarliGurbuz Erdogan

Abstract

Obesity is one of the most common diseases in the world. Particularly in elderly subjects, the effects of weight loss on cardiac functions have not been previously investigated by means of pulsed wave tissue doppler imaging (PWTDI). Using PWTDI, we examined the effects of weight loss on cardiac functions and left ventricular (LV) mass in obese geriatric women. Thirteen obese women aged 66-83 years (mean age 71.2+/-4.9 yrs) with a body mass index 35.6-49 kg/m2 (mean body mass index 39.9+/-4.3 kg/m2) were evaluated by echocardiography and PWTDI. Only subjects with uncomplicated obesity were included. All measurements, including anthropometric variables, systolic and diastolic indices, and LV mass, were made before and after a 6-month Orlistat plus hypocaloric diet. Myocardial systolic wave (Sm) velocity, isovolumic acceleration (IVA), myocardial precontraction time (PCTm) and the PCTm to contraction time (CTm) ratio were calculated as systolic indices. Early diastolic wave (Em), late diastolic wave (Am), Em to Am ratio, myocardial relaxation time (RTm), deceleration time (DT) and isovolumic relaxation time (IVRT) were determined as diastolic measurements. Subjects lost an average of 8.4+/-1.2 kg. LV mass decreased significantly a...Continue Reading

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Citations

Jan 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Cilla Haywood, Priya Sumithran
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

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