Effects of WIN 35,428 a potent antagonist of dopamine transporter on sleep and locomotor activity in rats

Neuroreport
Z de Saint HilaireJ M Gaillard

Abstract

The new cocaine derivative CFT naphthalene sulphonate (WIN 35,428), has been shown to have a considerably longer duration of action and greater potency than cocaine as a central stimulant and it appears to have a similar mode of action on dopamine (DA) systems. The purpose of the present study was first to investigate the effects of low doses of WIM 35,428 with particular reference to the involvement of dopaminergic system in paradoxical sleep (PS), other sleep parameters and locomotor activity in the rat. WIN 35,428 a potent ligand of dopamine transporter showed biphasic effects upon PS and locomotor activity with low doses increasing and high doses decreasing PS. These changes reflect a functional involvement probably relevant to the action of Win 35,428 on DA transporters.

Citations

Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Feb 7, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·María Cavas, José Francisco Navarro
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sunmee WeeWilliam L Woolverton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.