Effects of Withdrawing α1-Blocker from Combination Therapy with α1-Blocker and 5α-Reductase Inhibitor in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Prospective and Comparative Trial Using Urodynamics

The Journal of Urology
Yoshihisa MatsukawaMomokazu Gotoh

Abstract

We compared the effects on lower urinary tract symptoms and bladder outlet obstruction of combination therapy with α1-blocker and 5α-reductase inhibitor or a switch to 5α-reductase inhibitor monotherapy. We determined the factors influencing changes in lower urinary tract symptoms after α1-blocker withdrawal. A total of 140 outpatients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia received combination therapy with silodosin 8 mg per day and dutasteride 0.5 mg per day for 12 months. Of the patients 132 were randomized to continue combination therapy or switched to dutasteride monotherapy through silodosin withdrawal as the monotherapy group. Parameter changes from before randomization to 12 months after randomization were assessed based on subjective symptoms and urodynamic findings of voiding and storage function. Efficacy analysis included 57 patients on combination therapy and 60 on monotherapy. The change in I-PSS (International Prostate Symptom Score) after randomization was -0.7 and -0.6 in the combination therapy and monotherapy groups, respectively. The bladder outlet obstruction index changed from 46.1 to 41.8 in the combination therapy group and from 42.9 to 39.9 in the monotherapy group....Continue Reading

References

Apr 12, 2002·Neurourology and Urodynamics·Werner SchäferUNKNOWN International Continence Society
Dec 19, 2003·The New England Journal of Medicine·John D McConnellUNKNOWN Medical Therapy of Prostatic Symptoms (MTOPS) Research Group
Aug 26, 2006·Current Urology Reports·Sanjay KasturiKevin T McVary
Mar 24, 2007·Clinical Therapeutics·Michael J Naslund, Martin Miner
Sep 14, 2007·Scandinavian Journal of Urology and Nephrology·Naoya MasumoriUNKNOWN The Sapporo Medical University Naftopidil Study Group
Aug 14, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Taiji TsukamotoMichiro Narita
Nov 5, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaUNKNOWN Japanese Urological Association
Mar 26, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshihisa MatsukawaKotoko Mitsui
Jun 4, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Andrzej PomianEwa Barcz

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Citations

Nov 22, 2017·The Cochrane Database of Systematic Reviews·Jae Hung JungPhilipp Dahm
Dec 14, 2018·Advances in Therapy·Luca VillaFrancesco Montorsi

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