Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila

Molecular Biology and Evolution
John F BainesJohn Parsch

Abstract

Patterns of polymorphism and divergence in Drosophila protein-coding genes suggest that a considerable fraction of amino acid differences between species can be attributed to positive selection and that genes with sex-biased expression, that is, those expressed predominantly in one sex, have especially high rates of adaptive evolution. Previous studies, however, have been restricted to autosomal sex-biased genes and, thus, do not provide a complete picture of the evolutionary forces acting on sex-biased genes across the genome. To determine the effects of X-linkage on sex-biased gene evolution, we surveyed DNA sequence polymorphism and divergence in 45 X-linked genes, including 17 with male-biased expression, 13 with female-biased expression, and 15 with equal expression in the 2 sexes. Using both single- and multilocus tests for selection, we found evidence for adaptive evolution in both groups of sex-biased genes. The signal of adaptive evolution was particularly strong for X-linked male-biased genes. A comparison with data from 91 autosomal genes revealed a "fast-X" effect, in which the rate of adaptive evolution was greater for X-linked than for autosomal genes. This effect was strongest for male-biased genes but could be s...Continue Reading

References

Jun 25, 2013·Trends in Genetics : TIG·Richard P Meisel, Tim Connallon
Mar 25, 2011·Genetics Research·Brian Charlesworth
Jan 19, 2013·Nature Reviews. Genetics·John Parsch, Hans Ellegren
Apr 9, 2009·Molecular Biology and Evolution·Nadia D SinghCharles F Aquadro
Nov 21, 2009·Molecular Biology and Evolution·Judith E MankHans Ellegren
Oct 22, 2011·Molecular Biology and Evolution·Andrew D Moore, Erich Bornberg-Bauer
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Allen Orr
Jul 11, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard H BakerGerald S Wilkinson
Nov 13, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Amanda Glaser-SchmittJohn Parsch
Aug 28, 2010·Genome Research·Yong E ZhangManyuan Long
Feb 9, 2012·International Journal of Evolutionary Biology·Lena MüllerJohn Parsch
Dec 18, 2009·BMC Evolutionary Biology·Sonja GrathJohn Parsch
Feb 26, 2009·BMC Genomics·Miguel Pérez-EncisoManel López-Béjar
Mar 5, 2009·BMC Genomics·Xuejiang GuoJiahao Sha
Jun 9, 2009·PLoS Genetics·Guy SellaPeter Andolfatto
Oct 14, 2010·PLoS Genetics·Jeffrey M GoodMichael W Nachman
Oct 17, 2012·PLoS Genetics·Richard P MeiselAndrew G Clark
Nov 26, 2013·Molecular Biology and Evolution·Toni I GossmannKarl J Schmid
Feb 15, 2014·Molecular Biology and Evolution·Jennifer C PerryJudith E Mank
Oct 4, 2011·Trends in Genetics : TIG·Doris BachtrogNicole Valenzuela
Jun 3, 2008·Trends in Genetics : TIG·Daven C Presgraves
Aug 27, 2011·International Journal of Evolutionary Biology·Santosh JagadeeshanRama S Singh
May 29, 2009·Evolution; International Journal of Organic Evolution·Beatriz Vicoso, Brian Charlesworth
Jul 16, 2013·Journal of Evolutionary Biology·Alison E Wright, Judith E Mank
Jun 8, 2012·Evolution; International Journal of Organic Evolution·Ke XuSoojin V Yi
Feb 18, 2015·Molecular Ecology·Alison E WrightJudith E Mank

Citations

Jun 20, 1991·Nature·J H McDonald, M Kreitman
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·E Lifschytz, D L Lindsley
Nov 1, 1996·Genetics·A MochizukiY Iwasa
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·Willie J SwansonCharles F Aquadro
Apr 5, 2002·Nature·Carlos BustamanteDaniel L Hartl
May 29, 2002·Molecular Biology and Evolution·Kevin Thornton, Manyuan Long
Sep 25, 2002·Molecular Biology and Evolution·Andrea J BetancourtWillie J Swanson
Jul 2, 2003·Molecular Biology and Evolution·D G Torgerson, Rama S Singh
Jul 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David W RogersAndrew Pomiankowski
Dec 12, 2003·Bioinformatics·Julio RozasRicardo Rozas
Mar 11, 2004·Journal of Molecular Evolution·Stanley SawyerDaniel L Hartl
Mar 27, 2004·Molecular Biology and Evolution·Nicolas Bierne, Adam Eyre-Walker
May 4, 2004·Evolution; International Journal of Organic Evolution·Brian A CountermanMohamed A F Noor
Jul 9, 2004·Genetics·Xiaoxia Wang, Jianzhi Zhang
Jul 30, 2004·Molecular Biology and Evolution·Zhi ZhangJohn Parsch
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jian Lu, Chung-I Wu
Mar 5, 2005·Molecular Biology and Evolution·Matthew SpencerAndrew J Roger
May 5, 2005·PLoS Biology·Rasmus NielsenMichele Cargill
Jul 26, 2005·Trends in Genetics : TIG·Tim Connallon, L Lacey Knowles
Aug 27, 2005·Molecular Biology and Evolution·Josep M Comeron, Theodore B Guthrie
Sep 20, 2005·Current Biology : CB·Daven C Presgraves
Jul 4, 2006·Genetics·Muralidhar MettaChristian Schlötterer
Jul 19, 2006·Nature Reviews. Genetics·Beatriz Vicoso, Brian Charlesworth
Sep 5, 2006·Genetics·Matthias PröschelJohn Parsch
Nov 14, 2006·Nature Genetics·Steve DorusTimothy L Karr
Feb 8, 2007·Genome Biology·Penelope R HaddrillBrian Charlesworth
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joshua A ShapiroChung-I Wu
Feb 9, 2007·Genetics·John F Baines, Bettina Harr
Apr 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stanley SawyerDaniel L Hartl
Apr 10, 2007·Genome Research·Judith E MankHans Ellegren
May 31, 2007·Nature Genetics·Venkateswara R ChintapalliJulian A T Dow
Aug 8, 2007·Nature Reviews. Genetics·Hans Ellegren, John Parsch

Related Concepts

Drosophila melanogaster Proteins
Biological Adaptation
Drosophila
Gene Expression
Sequence Determinations, DNA
Genes, X-Linked
Psathyrella
Drosophila
Open Reading Frames
Genetic Polymorphism

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.