Effects of X-ray irradiation on natural killer (NK) cell system. I. Elevation of sensitivity of tumor cells and lytic function of NK cells.

Immunopharmacology and Immunotoxicology
A UchidaM Ikenaga

Abstract

The in vitro effect of X-ray irradiation on the human natural killer (NK) system was studied. When K562 cells were irradiated with X-rays and cultured for 18 hours, they showed increased sensitivity to lysis by blood lymphocytes and purified large granular lymphocytes (LGL). The X-ray-induced augmentation was observed as little as 2 Gy irradiation, reaching maximum at 5 to 20 Gy. The doses of X-rays did not influence the viability and spontaneous release of the target cells. On the other hand, irradiation with X-rays of NK cells at 5 to 15 Gy resulted in a transient increase in NK activity at 1 hour, and then the activity declined and was completely lost after 24 hours. However, when LGL were cultured with interferon immediately after irradiation, they maintained elevated NK activity. These results suggest the possible use of low doses of X-ray irradiation in combination with biological response modifiers for treatment of cancer.

References

Jan 1, 1976·Advances in Immunology·R E Anderson, N L Warner
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C C StewartR C Habbersett
May 15, 1985·International Journal of Cancer. Journal International Du Cancer·A Uchida, E Klein
Jan 1, 1985·Journal of Immunopharmacology·L J CharamellaN V Dimitrov
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·A Uchida, M Micksche

❮ Previous
Next ❯

Citations

Jun 1, 2005·Cancer Treatment Reviews·Joseph M KaminskiJeffrey Brousal
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Mar 23, 2011·Journal of Medical Case Reports·Kae OkumaKeiichi Nakagawa
Dec 1, 2009·Cases Journal·Preethi Bangalore LakshmanagowdaPramod Kallur
Jan 18, 2014·International Journal of Molecular Sciences·Bonggoo ParkKyung-Mi Lee
Oct 7, 2014·Biochimica Et Biophysica Acta·Morgan A O'BrienPatrick F Forde
Mar 21, 2013·International Journal of Radiation Biology·Meryem AkpolatUmmuhani Ozel Turkcu
Sep 3, 2008·Cell Biology International·Mahmoud R HusseinMohamed H Ahmad
Jan 29, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hiroshi WatanabeTakashi Imai
Dec 2, 2015·Future Oncology·Anita KumariCharlie Garnett-Benson
May 10, 2020·Seminars in Radiation Oncology·Arta M MonjazebKristina Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.