Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

Botanical Studies
Shen-Liang ShihWen-Chi Hou

Abstract

The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet (HF diet + dio50) for five weeks to check the changes of weights of body and tissues, blood pressures, and impaired glucose tolerances. The in vitro peptic hydrolysates of dioscorin with molecular mass between 3 kDa and 10 kDa and less than 3 kDa were used to determine dipeptidyl peptidase IV (DPP IV) inhibitory activities which DPP IV inhibitor has been reported to prevent and treat type 2 DM. There were no significant difference in body weights, feed intakes, feed conversion, and weights of adipose tissues of obese rats in groups of HF and (HF diet + dio50). However, the systolic blood pressures in obese rats of 2-, 3- and 4-week dioscorin interventions were showed significantly lower (P < 0.05) compared to the HF group. The dioscorin intervention (HF+ dio50) was showed signif...Continue Reading

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Citations

Sep 1, 2019·Journal of the Science of Food and Agriculture·Vasile Coman, Dan C Vodnar
Sep 27, 2019·Therapeutic Advances in Chronic Disease·Shian-Ren LinChing-Feng Weng
Jan 13, 2018·Journal of Agricultural and Food Chemistry·Hung-Ling HsiehKuo-Chih Lin
Sep 16, 2021·The British Journal of Nutrition·Waad Z AlharaziPreeti H Jethwa

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GraphPad Prism

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