PMID: 8602118Jan 1, 1996Paper

Effects of yew alkaloids and related compounds on guinea-pig isolated perfused heart and papillary muscle

Life Sciences
G AlloattiI Fenoglio

Abstract

The mechanical and electrical effects of selected yew alkaloids were studied on two different cardiac preparations: the isolated coronary perfused heart and the isolated papillary muscle of the guinea-pig. In the isolated heart, the Winterstein acid type alkaloids 1, 2 and 3 induced electrical and mechanical effects similar to those reported after yew intoxication (negative inotropic effect, block of atrio-ventricular conduction), but the coronary flow was unchanged. Taxine B (1), the most potent compound of this group, reduced cardiac contractility and the maximum rate of depolarisation of the action potential in the isolated papillary muscle, acting as a class I antiarrhythmic drug. In the isolated heart, the cinnamates 4 and 5, corresponding to the degradation products of 1 and 3, exerted arrhythmogenic effect due to a reduction of coronary flow. No alterations in electrical and contractile activities were in fact recorded after perfusion of the isolated papillary muscle with 4. Taxine A (6) and the taxane alcohol 7, corresponding to the terpenoid core of 3 had no significant cardiac effect. Our results suggest that the poisonous properties of the yew tree are probably due to the combined activity of alkaloids of the Winters...Continue Reading

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Citations

May 6, 2009·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Jessica PierogJ Ward Donovan
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Oct 29, 2003·Human & Experimental Toxicology·Petra Vichova, Ludek Jahodar
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Nov 16, 2021·Journal of Forensic Sciences·Elizabeth W L Brooks-LimAaron M Shapiro

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