Effects of ZD7114, a selective beta3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance

European Journal of Pharmacology
E SavontausM Koulu

Abstract

Selective beta3-adrenoceptor agonists increase energy expenditure by increasing non-shivering thermogenesis in brown adipose tissue. The aim of this study was to investigate how changes in energy balance affect energy intake and interaction of peripheral metabolic feedback signals with central neuroendocrine mechanisms participating in the control of body energy balance. Expression of preproneuropeptide Y (preproNPY) mRNA in the arcuate nucleus and preprocorticotropin-releasing factor (CRF) mRNA in the paraventricular nucleus were measured by in situ hybridisation technique after 1 day, 1 and 5 weeks of treatment with ZD7114 ((S)-4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]-N-(2-methoxyet hyl)phenoxyacetamide, 3 mg kg(-1) day(-1) in drinking water) in obese fa/fa Zucker rats. In addition, expression of leptin mRNA in epididymal fat and serum levels of leptin were analysed. Food intake, body weights, binding of GDP to brown adipose tissue mitochondria, plasma insulin and glucose were also measured. Treatment with ZD7114 significantly reduced weight gain and activated brown adipose tissue thermogenesis, but had no effect on food intake. Expressions of preproNPY or preproCRF mRNAs were similarly not changed by treatment with ZD7...Continue Reading

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Citations

Jul 25, 2003·European Journal of Pharmacology·Kouji Matsumoto, Hiroaki Iijima
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·E SavontausR Huupponen
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kendall M CarlinTracy L Bale
Jan 24, 2006·Bioscience, Biotechnology, and Biochemistry·Yun Chun Liu, Yasushi Hasegawa
Dec 4, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y Takakura, T Yoshida

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