PMID: 6974032Sep 7, 1981Paper

Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat

Brain Research
Y KressS Levine

Abstract

To test for in vivo zinc neurotoxicity on the cytoskeleton of neurotubules and intermediate filaments, Zn wires were implanted into the brains of adult Lewis rats for periods of 1-35 weeks. After 16 weeks of implant, some neurons showed bundles of intermediate filaments which were often localized in the perinuclear area. At the same time, occasional 200 nm tubular-like structures were seen in swollen dendrites. These structures were morphologically similar to Zn ion-induced aggregates of pure tubulin and structures found in ZnSO4-treated dorsal root ganglion organotypic cultures. The 200 nm structures in dendrites and the intermediate filaments in neurons increased in frequency with time. After 35 weeks of Zn wire implant, few microtubules could be found in the lesion. All the animals showed an astrocyte and glial filament proliferation with axoglial membrane specialization. Other wires studied: Pt, Ni, Co, Mg, demonstrate that Zn wires have a specific effect on cytoskeletal proteins in the CNS of the rat and many of the effects can be explained by an interaction between Zn and tubulin.

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Citations

Jan 1, 1988·Neuroscience·D W ChoiJ Koh
Apr 1, 1997·Brain Research. Brain Research Reviews·M P Cuajungco, G J Lees
Apr 8, 1998·Annual Review of Neuroscience·D W Choi, J Y Koh
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Mar 30, 2012·PloS One·Travis J A CraddockRudolph E Tanzi
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May 1, 1983·Medical Hypotheses·F E Barr
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Jan 1, 1997·Neurobiology of Disease·M P Cuajungco, G J Lees
Jan 1, 1999·Nutritional Neuroscience·M P CuajungcoA I Bush
Jan 4, 1983·Biochemistry·G R EagleR H Himes
Oct 17, 2017·Frontiers in Cellular Neuroscience·Laura J Blakemore, Paul Q Trombley
Mar 7, 2021·Biomedicines·Math P CuajungcoMarcelo E Tolmasky
Feb 8, 2000·Brain Research·M S HorningP Q Trombley

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