Effects of zinc oxide-eugenol on leucocyte number and lipoxygenase products in artificially inflamed rat dental pulp

Archives of Oral Biology
S HashimotoY Nakamura

Abstract

The number of leucocytes and level of endogenous LTC4 in the pulp tissue were measured by a histological method and radioimmunoassay, respectively. When the mandibular incisor pulp was irritated by drilling a hole in the dentine without using any coolant, the number of polymorphonuclear leucocytes and lymphocytes and the concentration of LTC4 increased to 3.2, 1.9 and 1.8 times their respective levels in normal pulp 6 h after the injury. The total leucocyte number in blood collected from these rats was also increased significantly. In contrast, when the cavities cut in dentine were filled with a zinc oxide-eugenol mixture (powder: liquid 100 mg/25 microliters), the increase in the number of cells was significantly curtailed, and the LTC4 level fell to 50% of that in normal pulp within 1 h after the filling. No decrease in the LTC4 level was observed after filling with a zinc oxide-water mixture, but the level decreased in response to an increase in eugenol content in the zinc oxide-eugenol placed in the cavity. Biosynthesis of [14C]-HETE and HPETE from [14C]-arachidonic acid was inhibited by the addition of 10 microM eugenol to the pulp homogenate. Thus eugenol released from zinc oxide-eugenol inhibited the biosynthesis of lipo...Continue Reading

References

Jan 1, 1985·International Archives of Allergy and Applied Immunology·G Marone
Jan 1, 1986·Journal of Dental Research·Y AzumaN Takagi
Jan 1, 1987·Archives of Oral Biology·T OkijiS Murota
May 29, 1985·Biochimica Et Biophysica Acta·J F EvansA W Ford-Hutchinson
Jul 1, 1966·Journal of Dental Research·A Obersztyn
Jun 1, 1969·Archives of Oral Biology·T Gotjamanos
May 1, 1970·Journal of Dental Research·A D Wilson, R F Batchelor
Jul 1, 1980·The Journal of Pharmacy and Pharmacology·M J SmithM A Bray
Feb 26, 1982·Biochemical and Biophysical Research Communications·S H SalariW S Powell
Sep 1, 1982·The Biochemical Journal·H WakeyamaS Minakami
Jan 1, 1983·Annual Review of Biochemistry·S Hammarström
Jan 1, 1984·Biochemical Pharmacology·F A KuehlE A Ham
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M DrazenE J Corey
Nov 1, 1980·British Journal of Clinical Pharmacology·S MannE B Raftery
Apr 1, 1949·Journal of Dental Research·R L GLASS, H A ZANDER

❮ Previous
Next ❯

Citations

Dec 8, 2009·Journal of Dentistry·Li-Hong HeMichael V Swain
Jun 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·K MarkowitzS Kim
Mar 19, 2003·Advances in Dental Research·M GoldbergL Stanislawski
Aug 14, 2001·Journal of Dental Research·P ChaudharyT K Baumann
Aug 15, 2001·Journal of Endodontics·S BelliD H Pashley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.