Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice

Biological Trace Element Research
M D ChenW H Lin

Abstract

The effects of zinc supplementation (20 mM ZnCl2 from the drinking water for eight weeks) on plasma glucose and insulin levels, as well as its in vitro effect on lipogenesis and lipolysis in adipocytes were studied in genetically obese (ob/ob) mice and their lean controls (+/?). Zinc supplementation reduced the fasting plasma glucose levels in both obese and lean mice by 21 and 25%, respectively (p < 0.05). Fasting plasma insulin levels were significantly decreased by 42% in obese mice after zinc treatment. In obese mice, zinc supplementation also attenuated the glycemic response by 34% after the glucose load. The insulin-like effect of zinc on lipogenesis in adipocytes was significantly increased by 80% in lean mice. However, the increment of 74% on lipogenesis in obese mice was observed only when the zinc plus insulin treatment was given. This study reveals that zinc supplementation alleviated the hyperglycemia of ob/ob mice, which may be related to its effect on the enhancement of insulin activity.

References

May 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S R JollyL A Menahan
Oct 15, 1979·The Biochemical Journal·J A CarnieM Mavris-Vavayannis
Jan 1, 1992·Biological Trace Element Research·P FaureA Favier
Aug 1, 1992·Endocrine Reviews·H Yki-Järvinen
Nov 1, 1988·The American Journal of Clinical Nutrition·M D ChenV Cheng
Jan 1, 1988·Methods in Enzymology·K H FalchukB L Vallee
May 1, 1987·The Journal of Nutrition·M L Kennedy, M L Failla
Aug 1, 1980·Diabetes·L Coulston, P Dandona
Jan 1, 1995·Biological Trace Element Research·J F BrunA Orsetti
Apr 1, 1994·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·J A Fernández-LópezM Alemany
Jan 1, 1994·Medical Hypotheses·J E Sprietsma, G E Schuitemaker
Mar 1, 1981·Biological Trace Element Research·H P Roth, M Kirchgessner

❮ Previous
Next ❯

Citations

Dec 24, 1997·Biological Trace Element Research·M D ChenW H Sheu
Sep 1, 1999·Biological Trace Element Research·M D ChenW H Sheu
Sep 21, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yusuke AdachiHiromu Sakurai
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hajo Haase, Wolfgang Maret
Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Jul 31, 2007·Obesity Surgery·Liliane Viana PiresDilina do Nascimento Marreiro
Sep 19, 2008·Biological Trace Element Research·Richard ClaeyssenDiane Agay
Oct 28, 2008·Biological Trace Element Research·Ming-Der Chen, Yuh-Min Song
Sep 18, 2009·Biological Trace Element Research·Julie Calixto LoboDenise Mafra
Jan 29, 2011·Biological Trace Element Research·Saeed AkhtarAnwaar Ahmed
May 29, 2013·Biological Trace Element Research·Saori KadowakiShuichi Enomoto
Jun 26, 2012·Journal of Physiology and Biochemistry·Parichehreh YaghmaeiAzadeh Ebrahim-Habibi
Dec 25, 2002·Clinical Biochemistry·Metin OzataI Caglayan Ozdemir
Feb 1, 2003·The Journal of Nutritional Biochemistry·Diana L Tallman, Carla G Taylor
Oct 25, 2008·Chemical Society Reviews·Hiromu SakuraiHiroyuki Yasui
Aug 5, 2003·Journal of the American College of Nutrition·Anne-Marie RousselRichard A Anderson
Jun 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yutaka YoshikawaHiroyuki Yasui
Sep 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Patrice Faure
Jun 27, 2009·The Review of Diabetic Studies : RDS·Esfandiar HeidarianAshraf Aminorroaya
Jan 1, 2010·The Review of Diabetic Studies : RDS·Mariea D BoscoP Toby Coates
Apr 29, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Surapun TepaamorndechLiping Huang
Jan 2, 2009·Digestive Diseases and Sciences·Sema BolkentOzgur Mutlu
Jun 1, 2007·Expert Opinion on Drug Discovery·Hiromu Sakurai
Nov 10, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jasmine CapdorSamir Samman
Mar 3, 2004·Experimental Animals·Masaya KawaseKiyohito Yagi
Jul 24, 2012·Free Radical Biology & Medicine·Srinivasan Dinesh KumarSamuel Sam Wah Tay
May 9, 2009·British Journal of Pharmacology·M K SongE M Cornford
Oct 15, 2005·Biotechnology and Bioengineering·Victor V T WongMiranda G S Yap
Oct 21, 2006·Biochemical and Biophysical Research Communications·Yusuke AdachiHiromu Sakurai
Mar 31, 2016·Biological Trace Element Research·Krishna Prahlad MaremandaG B Jena
Apr 25, 2006·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wolfgang Maret, Harold H Sandstead
Jan 13, 2015·Journal of Animal Physiology and Animal Nutrition·N JafarpourM Hosseini Ghaffari
Oct 2, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yutaka Yoshikawa
Aug 14, 2012·Current Opinion in Pharmacology·Inge Depoortere

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.