Effects of zoledronic acid and ibandronate in the treatment of cancer pain in rats with lung cancer combined with bone metastases

Oncology Letters
Gengshen WangCunliang Niu

Abstract

The aim of the study was to investigate the efficiency and safety of zoledronic acid and ibandronate in the treatment of rats with lung cancer combined with bone metastases. A total of 124 rats with lung cancer bone metastasis were established. Rats were randomly divided into A, B and C groups (n=30). Rats in group A were treated with ibandronate combined with zoledronic acid, rats in group B were treated with zoledronic acid monotherapy, and rats in group C were treated with ibandronate monotherapy. Rats in group A were injected subcutaneously with zoledronic acid 0.1 mg/kg and ibandronate 10 µg/kg, once per week for 12 weeks; rats in group B were injected subcutaneously with zoledronic acid, and rats in group C were injected subcutaneously with ibandronate, the same method as the treatment group. The remaining 34 SD rats were not treated to serve as the control group. Treatment efficacy and physical improvement in 8 weeks were observed, and improvement of pain behavior in rats was evaluated to reflect the effect of drug treatment. Of the 30 rats in group A, 25 showed different degrees of remission, 5 rats showed no improvement and the effective rate was 83.3%. Of the 30 rats in group B, 21 showed different degrees of remissio...Continue Reading

References

Mar 17, 2012·Journal of the National Cancer Institute·Suresh H MoolgavkarEric J Feuer
Oct 29, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·David HenryHoward Yeh
Jan 1, 2014·Annals of Internal Medicine·Virginia A Moyer, UNKNOWN U.S. Preventive Services Task Force
Feb 6, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Robert E MillerWilliam C Dougall
Feb 15, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Lortet-TieulentF Bray
May 3, 2014·Therapeutic Advances in Medical Oncology·Chiara D'AntonioFilippo de Marinis
Jul 3, 2015·Therapeutic Advances in Medical Oncology·Shobha C SilvaPenella J Woll
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 27, 2015·Biochemical and Biophysical Research Communications·Fan XieJingping Ma
Dec 30, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Claire TissotPierre-Jean Souquet
Jan 1, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lizza E L HendriksAnne-Marie C Dingemans
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators

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