Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats

Obesity
Marianne F BennetzenSteen B Pedersen

Abstract

Endocannabinoids act through the cannabinoid receptor 1 (CB1) and has both orexigenic and peripheral metabolic effects. It is not yet fully understood whether all the beneficial effects on the metabolic profile by CB1 antagonism are induced by the weight loss or also by direct peripheral effects. The present study was intended to further elucidate this question and to investigate whether tolerance development to the hypophagic effect could be attenuated by cyclic treatment. We performed an intervention study in 40 lean rats over 4 weeks. The rats were divided in four groups: a control group, two groups treated with the CB1 antagonist Rimonabant either continuously or cyclically, and one group pair fed with the continuous Rimonabant group to obtain the same body weight. During the first 6 days, food intake was less in the continuous Rimonabant group compared to the control group (P < 0.01). Throughout the study period, the cyclic Rimonabant group had a smaller food intake than the continuous Rimonabant group (P < 0.05). After 4 weeks, the cyclic Rimonabant group had a reduced weight gain compared to the control group (P < 0.05). Serum levels of glycerol and free fatty acids (nonesterified fatty acid, NEFA) were significantly red...Continue Reading

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Citations

Dec 25, 2010·Addiction Biology·Mónica Méndez-DíazOscar Prospéro-García
Feb 4, 2010·Journal of Atherosclerosis and Thrombosis·Koichi SugamuraHisao Ogawa
Jun 16, 2015·Pharmacology, Biochemistry, and Behavior·Mónica Méndez-DíazOscar Prospéro-García

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