PMID: 7543131Aug 1, 1995Paper

Effects on glucose tolerance, insulin secretion, insulin-like growth factor 1 and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men

Journal of Internal Medicine
M L HelleniusU de Faire

Abstract

To study the effects of advice on diet, exercise and their combination on oral glucose tolerance (OGTT), insulin secretion, insulin-like growth factor-1 (IGF-1) and its binding protein, IGFBP-1. A 6-month, randomized, controlled intervention study. Primary health care centres in Sollentuna, Stockholm and the Department of Medicine, Karolinska Hospital, Stockholm, Sweden. One hundred and fifty-seven normoglycaemic healthy men, mean age 46 years, range 35-60 years, with slightly to moderately raised cardiovascular risk factors. Advice on diet (D, n = 40), exercise (E, n = 39) a combination of both (DE, n = 39) and a control group (C, n = 39). An OGTT, insulin secretion, IGF-1 and its binding protein, IGFBP-1. The number of pathological OGTTs in the intervention groups decreased from 42/118 to 33/118 whilst the number in the control group did not change. Fasting insulin levels decreased in groups E and DE from 8.8-7.4 mU L-1 (P < 0.01) and from 8.3-6.7 mU L-1 (P < 0.01), respectively. Accordingly, the insulin area under the curve decreased from 5278 to 4828 (P < 0.05) in group E, and from 5482 to 4809 (P < 0.01) in group DE. IGF-1 only increased in group D. The most prominent changes were noted for IGFBP-1, which increased in all ...Continue Reading

References

Jan 1, 1976·The American Journal of Medicine·G M ReavenJ M Olefsky
May 9, 1992·Lancet·F S FacchiniG M Reaven
Jul 1, 1992·The American Journal of Clinical Nutrition·V HainerP Hrabák
Feb 15, 1992·The American Journal of Cardiology·R J BarnardS B Inkeles
Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M BorkmanL H Storlien
Sep 28, 1991·BMJ : British Medical Journal·E T SkarforsH O Lithell
Jun 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·H LundgrenJ Waldenström
Sep 1, 1988·Journal of Endocrinological Investigation·K BrismarK Hall
Apr 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, F A Gries
Jan 1, 1985·Acta Medica Scandinavica·J Cederholm, L Wibell
Aug 1, 1970·Metabolism: Clinical and Experimental·P BjörntorpL Sullivan
Jan 1, 1983·Metabolism: Clinical and Experimental·A M CoulstonG M Reaven
Feb 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·I HjermannI Holme
Sep 1, 1993·European Journal of Clinical Investigation·K S Langford, J P Miell
Jan 1, 1994·Journal of Internal Medicine·I ZavaroniG M Reaven
May 1, 1993·American Journal of Epidemiology·M Laakso
Apr 1, 1993·Trends in Endocrinology and Metabolism : TEM·R C Baxter

❮ Previous
Next ❯

Citations

Sep 25, 2003·Metabolism: Clinical and Experimental·Jeffrey A PotteigerUNKNOWN Midwest Exercise Trial
Jul 19, 2013·PloS One·Helene RundqvistArne Östman
Jan 1, 2012·Scientifica·Callum Livingstone
Apr 8, 2009·Trends in Endocrinology and Metabolism : TEM·Stephen B Wheatcroft, Mark T Kearney
Aug 29, 2007·Pediatric Clinics of North America·Sergio R R Buzzini
Sep 4, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S RössnerK Johansson
Jun 11, 2009·Scandinavian Journal of Medicine & Science in Sports·E SillanpääD E Laaksonen
Jan 1, 1995·Progress in Growth Factor Research·K BrismarB Lindgren
Mar 25, 2015·Prostate Cancer and Prostatic Diseases·A WekesaR W Watson
Dec 24, 2004·Diabetes·David E LaaksonenUNKNOWN Finnish diabetes prevention study
Sep 1, 1999·Clinical Endocrinology·P J Jenkins
Oct 12, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael J ReddIshay Ostfeld
Aug 31, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P J Jenkins
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Aug 8, 2001·The Journal of Urology·C N TymchukW J Aronson
Oct 5, 2006·International Journal of Cancer. Journal International Du Cancer·Tom I L NilsenLars J Vatten
Jan 28, 2005·The Cochrane Database of Systematic Reviews·M HillsdonM Thorogood
Oct 22, 2008·European Journal of Epidemiology·Fredrik WiklundHenrik Grönberg
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Fitsum Guebre-EgziabherDenis Fouque
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Jan 1, 2013·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Magnus HagmarAngelica Lindén Hirschberg
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 2, 2020·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.