Effects on human skin of repetitive ultraviolet-A1 (UVA1) irradiation and visible light

Photodermatology, Photoimmunology & Photomedicine
D W EdströmA M Ros

Abstract

Ultraviolet radiation (UVR) has a variety of effects on human skin. Best known are the effects of UVB (290-320 nm) and UVA2 (320-340 nm), which cause DNA damage and increased risk of cancer. However, the effects of UVA1 (340-400 nm) have been not completely investigated. The effects of repetitive low doses of UVA1 and visible light were studied in 12 healthy individuals. A part of the buttock was exposed to 20 J/cm2 UVA1 and another part of 126 J/cm2 of visible light three times a week for 4 weeks. Repeated punch biopsies were taken during the 4 weeks of treatment and also 2 weeks after the last irradiation. The avidin-biotin-immunoperoxidase technique was used to investigate the expression of p53, p21WAF, bcl-2, Ki67 and cyclin A. By comparison to untreated skin, an increased expression of p53 but not p21WAF in keratinocytes was seen. The bcl-2 protein expression increased slightly after both UVA1 and visible light. An increased staining with Ki67 and cyclin A after UVA1 but not after visible light was observed as a sign of increased proliferation. These results suggest that suberythemal doses of UVA1 and even visible light may cause DNA damage.

Citations

May 13, 2005·The British Journal of Dermatology·P E BeattieS H Ibbotson
Apr 9, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A MartínezM I Rudolph
Oct 31, 2018·Journal of Cosmetic Dermatology·Bakr Mohamed El-ZawahryAmira Ragab
Apr 22, 2009·The Analyst·Andrew Mills, Pauline Grosshans
Oct 30, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jonathan A PaleroHans C Gerritsen
Jan 27, 2012·Clinical and Experimental Dermatology·A C KerrR P E Sarkany
Feb 22, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Pascale QuatresoozGérald E Piérard
Jan 22, 2003·Photodermatology, Photoimmunology & Photomedicine·Asa E PerssonCecilia Williams
Oct 19, 2004·Medical Physics·Günther SchaubergerUNKNOWN European Cosmetic Toiletry and Perfumery Association
Dec 8, 2006·Dermatitis : Contact, Atopic, Occupational, Drug·Sabra M Lofgren, Erin M Warshaw
Feb 6, 2008·Photochemistry and Photobiology·Bassel H MahmoudHenry W Lim
Apr 26, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·G Hofbauer
Jun 12, 2017·Photodermatology, Photoimmunology & Photomedicine·Luc DuteilThierry Passeron
Jan 15, 2010·Photodermatology, Photoimmunology & Photomedicine·Marloes M KleinpenningRianne M J P Gerritsen
Aug 3, 2021·International Journal of Radiation Biology·Alena RyšaváAlena Rajnochová Svobodová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.