Effects on improvement of blood flow in the chronically compressed cauda equina: comparison between a selective prostaglandin E receptor (EP4) agonist and a prostaglandin E1 derivate

Spine
Miho SekiguchiShin-Ichi Kikuchi

Abstract

Vasodilatation was studied in a model of experimental chronic cauda equina compression using measurements of vessel diameter on video recordings. The vasodilative effect was compared between a prostaglandin E2 receptor (EP) subtype agonists (EP4 agonist) and a prostaglandin E1 (PGE1) derivate. Reduction of blood flow is one important pathogenic factor of neurogenic intermittent claudication (NIC) for lumbar spinal canal stenosis. It is known that PGE1 improves the mean walking distance in patients with cauda equina compression type of NIC. There are four subtypes of EP: EP1, EP2, EP3, and EP4. EP4 is located in vessels of pigs and rabbits. A highly selective EP4 agonist, which has effects on dilatation of pig and rabbit vessels, has recently been developed. One may therefore assume that this agonist may improve blood flow in the chronically compressed cauda equina. A total of 25 dogs were used. A plastic balloon inflated to 10 mm Hg was placed under the lamina of the seventh lumbar vertebra for 1 week. OP-1206 cyclodextrin clathrate (OP-1206 CD: prostaglandin E1 derivate) and ONO-4819 CD (a highly selective EP4 agonist) were intravenously administrated. The following 5 experimental groups were assigned: animals in group OP (3) ...Continue Reading

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Citations

Nov 2, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Miho SekiguchiShin-ichi Kikuchi
Oct 24, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Akira OndaShin-Ichi Konno
Jan 23, 2015·Pain Practice : the Official Journal of World Institute of Pain·Hiroyuki Yoshihara
Oct 26, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Takehiro UmemuraKenji Okajima
Aug 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mitsuko TakenagaTohru Mizushima
Dec 1, 2009·International Journal of Obstetric Anesthesia·S KoyamaY Murata
Mar 27, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shigeru KobayashiYoshihiko Suzuki

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