Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generation

American Journal of Physiology. Renal Physiology
J SatrianoR C Blantz

Abstract

Agmatine, decarboxylated arginine, is produced in the kidney and can increase nephron and kidney filtration rate via renal vasodilatation and increases in plasma flow. This increase in filtration rate after agmatine is prevented by administration of nitric oxide synthase (NOS) inhibitors. In endothelial cells, agmatine-stimulated nitrite production is accompanied by induction of cytosolic calcium. NOS activity requires calcium for activation; however, the source of this calcium remains unknown. Ryanodine receptor (RyR) calcium-activated calcium release channels are present in the kidney cortex, and we evaluated if RyR contributes to the agmatine response. Agmatine microperfused into Bowman's space reversibly increases nephron filtration rate (SNGFR) by approximately 30%. cADP-ribose (cADPR) regulates RyR channel activity. Concurrent infusion of agmatine with the cADPR blocker 8-bromo-cADPR (2 microM) prevents the increase in filtration rate. Furthermore, direct activation of the RyR channel with ryanodine at agonist concentrations (5 microM) increases SNGFR, and, like agmatine, this increase is prevented by administration of N(G)-monomethyl-l-arginine, a nonselective NOS blocker. We demonstrate that agmatine does not elicit ADP...Continue Reading

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Citations

May 1, 2009·American Journal of Physiology. Renal Physiology·Tiffany L Thai, William J Arendshorst
Jun 6, 2008·American Journal of Physiology. Renal Physiology·Tiffany L Thai, William J Arendshorst
Jun 19, 2013·Drug Discovery Today·John E PiletzGad M Gilad
Jan 4, 2012·Pharmacology & Therapeutics·Gerhard J Molderings, Britta Haenisch
Mar 12, 2016·Journal of Pharmaceutical and Biomedical Analysis·Yong-Hui LiJun-Qing Zhang
Mar 3, 2017·Journal of Inherited Metabolic Disease·Julien BaruteauJames E Davison
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·William J Arendshorst, Tiffany L Thai
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·Fredrik PalmPeter Hansell
Jun 10, 2015·Journal of Neurosurgical Anesthesiology·Jeong Min KimBon-Nyeo Koo
Apr 16, 2021·PloS One·Iva ChitrakarJarrod B French
May 6, 2021·International Journal of Molecular Sciences·Pablo MaturanaElena Uribe
Jan 31, 2015·Journal of Inorganic Biochemistry·Matías QuiñonesElena Uribe

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