PMID: 130154Feb 1, 1976

Effects on non-depolarizing neuromuscular blocking agents on peripheral autonomic mechanisms in cats

British Journal of Anaesthesia
R Hughes, D J Chapple

Abstract

Intravenous dose-response relationships were used to correlate neuromuscular paralysis with effects on autonomic mechanisms in anaesthetized cats. Whereas autonomic blockade with tubocurarine occurred at parasympathetic and sympathetic ganglia, neuromuscular paralysing doses of gallamine, alcuronium, pancuronium and fazadinium caused blockade at vagal postganglionic sites in the heart. The vagolytic (atropinic) activity of these compounds in cats relative to their neuromuscular blocking activity appeared to correlate well with their known liability to cause undesirable hypertension and tachycardia in man. The absence of cardiovascular effects after the administration of neuromuscular blocking doses of dimethyl tubocurarine would support its more extensive clinical use, but the need remains for a short-acting muscle relaxant with properties similar to those of dimethyl tubocurarine.

Citations

Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·A D Fryer, J Maclagan
Dec 1, 1985·Pflügers Archiv : European journal of physiology·M PassatoreG M Filippi
Jan 1, 1976·Canadian Anaesthetists' Society Journal·R HughesN Sugai
Nov 1, 1982·Canadian Anaesthetists' Society Journal·A J CunninghamA G Watson
Jan 1, 1984·Canadian Anaesthetists' Society Journal·B P KingsleyR W Vaughan
Jul 9, 1982·European Journal of Pharmacology·V P CherepanovaS F Torf
Jan 1, 1987·Journal of Psychosomatic Research·A S Salim
May 1, 1988·Metabolism: Clinical and Experimental·O WisénC Johansson
Nov 1, 1982·Journal of the Autonomic Nervous System·M Passatore, G M Filippi
Jan 1, 1991·General Pharmacology·W M DavisI W Waters
Jun 24, 2000·Anaesthesia·A G McKenzie
Jul 1, 1978·Anaesthesia·M JohnstoneR A Mrozinski
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·P Hommelgaard, S Eriksen
Jun 1, 1988·Acta Physiologica Scandinavica·N H SecherH Galbo
Dec 1, 1979·The Journal of Pharmacy and Pharmacology·S E Drane, M H Evans
Jan 1, 1993·Intensive Care Medicine·B J Pollard
Aug 1, 1984·Journal of Pharmacological Methods·R Hughes
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·L LindgrenL Saarnivaara
Feb 1, 1981·Acta Anaesthesiologica Scandinavica·J HeinonenO Takkunen
Feb 1, 1981·Acta Anaesthesiologica Scandinavica·G G CokerR D Waigh
Jul 6, 2014·Veterinary Anaesthesia and Analgesia·Kristoffer GrongGeir O Dahle
May 1, 1989·Acta Anaesthesiologica Scandinavica·G H HackettG Earnshaw
Jul 1, 1981·The Journal of Pharmacy and Pharmacology·I G MarshallD Paul

Related Concepts

Acetylcholine Sulfate (1: 1)
Dialferine
Autonomic Nervous System
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Neuromuscular Nondepolarizing Agents
Dose-Response Relationship, Drug
Gallamine
Autonomic Ganglion

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