PMID: 20650140Oct 1, 1995Paper

Effects on rat embryos of culture in serum of women with gestational diabetes

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Asher OrnoyI Raz

Abstract

Serum from diabetic patients, as well as having high levels of glucose and ketone bodies, is known to have embryotoxic and teratogenic effects that play an important role in diabetes-induced teratology. We studied the effect of serum from women with gestational diabetes, who are not known to have a high incidence of malformations in their offspring, on the in vitro development of 10.5-day-old rat embryos. Results from these studies were then compared with those using serum from pregnant women with Type I diabetes, serum from pregnant women without diabetes, and normal rat serum. Serum from pregnant women with Type I diabetes caused abnormalities in 71% of the embryos in comparison with an incidence of 53.3% in embryos cultured in serum from women with gestational diabetes. Embryos cultured in serum from women without diabetes or in rat serum had a 9 and 4.2% incidence of defects, respectively. Diabetic serum also decreased the size of the embryos, the number of somites, yolk sac diameter, and the amount of protein in the embryos and their yolk sacs. This damage was more significant when embryos were cultured in Type I diabetic serum than in serum from patients with gestational diabetes. The levels of serum glucose, glycosylated...Continue Reading

References

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Mar 1, 1977·Obstetrical & Gynecological Survey·S G Gabbe
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Mar 1, 1981·Clinical Obstetrics and Gynecology·S G Gabbe, E J Quilligan

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Citations

Mar 19, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Asher OrnoyRichard Kermit Miller
Jun 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yao ChenXuesong Yang
Nov 30, 2010·Diabetes Research and Clinical Practice·R G Ahmed

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