PMID: 7026329May 1, 1981Paper

Effects on rat fetuses of intrauterine injections of insulin

Diabetologia
L AngervallA Martinson

Abstract

The effects on rat fetuses of a single intrauterine injection of long-acting insulin with respect to length, body and organ weights, total lipids, phospholipids, cholesterol, neutral fat, total nitrogen and water content were investigated. At the age of 498 hours the fetuses were injected in utero with 2 IU of long-acting insulin or a control solution. Twenty-four hours after the injections the insulin-treated fetuses weighed about 10 per cent more than the control fetuses, 5.32 +/- 0.05 g (75 fetuses) and 4.85 +/- 0.05 (73 fetuses) respectively (p less than 0.001). The body lengths were 54.1 +/- 0.2 mm and 52.9 +/- 0.2 mm respectively (p less than 0.001). The insulin-treated fetuses had higher organ weights and higher content of total lipids, phospholipids and neutral fat. The amount of total lipids was higher in insulin-treated fetuses even after taking into account differences in body weight, suggesting that the insulin-treated fetuses were obese. The finding of significantly lower water content in insulin-treated fetuses at equal body weight is consistent with the higher fat content. There was no increase in total nitrogen or length in the fetuses in the insulin-treated group compared to control fetuses at equal body weight...Continue Reading

Citations

Mar 21, 1998·The Journal of Nutrition·E A Liechty, S C Denne
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Weihua ShenEdward A Liechty
May 19, 2020·Placenta·Ashley K EdwardsM Carey Satterfield
Oct 1, 1993·The American Journal of Physiology·E A LiechtyS C Denne
Dec 1, 1985·Metabolism: Clinical and Experimental·E A CatlinW Oh

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