Effects on T-cell maturation and proliferation induced by lactational transfer of cyclosporine to nursing pups

Transplantation
Eric L Padgett, Leonard L Seelig

Abstract

Pregnancy after allotransplantations is becoming a more common occurrence, and the immunosuppressant of choice is cyclosporine (CsA) for these patients. Consequently, the effect of CsA on prenatal and postnatal immune development and function in the infant is an increasingly important clinical issue. The purpose of this study was to evaluate the potential problems of maternal CsA exposure on neonatal T-cell maturation and proliferation after lactational transfer of CsA in an animal model. CsA was administered daily (subcutaneous) for 20 days during lactation, beginning the day of parturition using two dose levels (15 and 25 mg/kg body weight/day) in conjunction with saline controls. Considerable amounts of CsA were passed to the newborn rats with neonatal blood levels equal to that of the mothers for the 25-mg/kg/day dose and 55% for the 15 mg/kg dose. There was a significant reduction in thymus/body-weight ratio and thymus cellularity for the pups born to mothers dosed at 15 or 25 mg/kg/day of CsA. The thymus from the CsA-exposed pups showed an almost complete loss of the medullary region with no apparent change in the thymic cortex. The CsA-treated mothers and their pups (15 and 25 mg/kg/day dose) had a significant increase i...Continue Reading

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Citations

Apr 29, 2009·Reproductive Toxicology·Linda AllaisPaul C Barrow
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dianne B McKayUNKNOWN Women's Health Committee of the American Society of Transplantation
May 23, 2006·Pediatric Transplantation·Mehmet Atilla TürkmenHülya Güven
Oct 27, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Paul C BarrowGuillaume Ravel
Apr 5, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S SasoJ R Smith
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Nov 10, 2009·Human Reproduction Update·Mats BrännströmAlbert Altchek

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