Effects on the liver in the rat of ingestion of Indigofera spicata, a legume containing an inhibitor of arginine metabolism

The Journal of Pathology
G S ChristieM P Hegarty

Abstract

The non-protein amino acid indospicine, which occurs in the free state in high concentration in the tropical pasture legume Indigofera spicata, causes toxic liver lesions in ruminants. Indospicine is a specific antagonist of arginine and an inhibitor of protein synthesis. The liver lesion was studied in rats at four dose levels by feeding diets containing 96, 48, 24 and 15 per cent. of the seed. The too higher levels caused death of most animals in 2-6 wk. Females were more susceptible than males. The rats fed the 24 per cent. seed diet developed a nodular cirrhosis by 6 wk and survived up to 18 wk. The rats fed the 15 per cent. seed diet developed cirrhosis at 16 wk and survived up to 28 wk. Prior to the onset of cirrhosis the liver showed a characteristic lesion consisting of hepatomegaly, periportal fatty change, portal cellularity due to proliferation of ovoid and cuboidal duct cells, gross enlargement of the hepatocyte cytoplasm nuclei and nucleoli in spite of brisk mitotic activity, and focal centrilobular necrosis. The lesion was interpreted as a restricted hepatic response to a growth stimulus, possibly the mobilisation of tissue amino acids. Improvement occurred in the rats fed the two lower dosage levels after nodular...Continue Reading

References

Apr 1, 1972·Pathology·F G De MunkM P Hegarty
Jan 27, 1968·Nature·M P Hegarty, A W Pound
Mar 10, 1958·The Journal of Nutrition·E M HUTTONC C KRATZING
Jul 10, 1958·The Journal of Nutrition·E M HUTTONC C KRATZING

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Citations

Jul 31, 2013·Journal of Natural Products·Lynette Bueno PérezA Douglas Kinghorn
Nov 1, 1988·Australian Veterinary Journal·M P HegartyR Cameron
Aug 2, 2016·Journal of Agricultural and Food Chemistry·Eddie T T TanMary T Fletcher
Aug 11, 2016·Journal of Agricultural and Food Chemistry·Eddie T T TanMary T Fletcher
Aug 31, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Eddie T T TanMary T Fletcher
Aug 1, 1978·Journal of Human Nutrition·F J Ballard
Sep 1, 1978·The British Journal of Nutrition·S E Knowles, F J Ballard
Mar 26, 2013·Australian Veterinary Journal·S M OssedryverM T Fletcher
Feb 18, 2011·Australian Veterinary Journal·L M FitzGeraldA J O'Hara
Mar 19, 2019·Toxicon : Official Journal of the International Society on Toxinology·Gabriele NetzelMary T Fletcher
May 2, 2003·Journal of Agricultural and Food Chemistry·E Arthur Bell

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